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Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation

Inverted papilloma (IP) is a common benign tumor in the nose and sinus. Osteogenesis in sinonasal IP is extremely rare; to date, only five cases of IP with new bone formation appear in the literature. In addition, the mechanism of osteogenesis in IP remains unclear. Here, we describe three cases of...

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Autores principales: Okamoto, Tomoyo, Kodama, Satoru, Nomi, Nozomi, Umemoto, Shingo, Suzuki, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OceanSide Publications, Inc. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390124/
https://www.ncbi.nlm.nih.gov/pubmed/22852110
http://dx.doi.org/10.2500/ar.2011.2.0004
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author Okamoto, Tomoyo
Kodama, Satoru
Nomi, Nozomi
Umemoto, Shingo
Suzuki, Masashi
author_facet Okamoto, Tomoyo
Kodama, Satoru
Nomi, Nozomi
Umemoto, Shingo
Suzuki, Masashi
author_sort Okamoto, Tomoyo
collection PubMed
description Inverted papilloma (IP) is a common benign tumor in the nose and sinus. Osteogenesis in sinonasal IP is extremely rare; to date, only five cases of IP with new bone formation appear in the literature. In addition, the mechanism of osteogenesis in IP remains unclear. Here, we describe three cases of IP with new bone formation and an investigation into a possible role for bone morphogenic protein (BMP) in osteogenesis. Of three patients with sinonasal IP with new bone formation, two were treated by endoscopic sinus surgery and one was followed up with watchful waiting. Tumor tissues were subjected to immunohistochemistry to detect BMP expression. The patients were successfully treated surgically and showed no evidence of recurrence postoperatively. Follow-up examination is ongoing. Immunohistochemically, the tumors expressed BMP-4 but not BMP-2 or BMP-7. ESS could be successfully used to achieve complete removal of the sinonasal IPs with new bone formation. BMP-4 might be associated with new bone formation in the tumor.
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spelling pubmed-33901242012-07-31 Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation Okamoto, Tomoyo Kodama, Satoru Nomi, Nozomi Umemoto, Shingo Suzuki, Masashi Allergy Rhinol (Providence) Articles Inverted papilloma (IP) is a common benign tumor in the nose and sinus. Osteogenesis in sinonasal IP is extremely rare; to date, only five cases of IP with new bone formation appear in the literature. In addition, the mechanism of osteogenesis in IP remains unclear. Here, we describe three cases of IP with new bone formation and an investigation into a possible role for bone morphogenic protein (BMP) in osteogenesis. Of three patients with sinonasal IP with new bone formation, two were treated by endoscopic sinus surgery and one was followed up with watchful waiting. Tumor tissues were subjected to immunohistochemistry to detect BMP expression. The patients were successfully treated surgically and showed no evidence of recurrence postoperatively. Follow-up examination is ongoing. Immunohistochemically, the tumors expressed BMP-4 but not BMP-2 or BMP-7. ESS could be successfully used to achieve complete removal of the sinonasal IPs with new bone formation. BMP-4 might be associated with new bone formation in the tumor. OceanSide Publications, Inc. 2011 /pmc/articles/PMC3390124/ /pubmed/22852110 http://dx.doi.org/10.2500/ar.2011.2.0004 Text en Copyright © 2011, OceanSide Publications, Inc., U.S.A. This publication is provided under the terms of the Creative Commons Public License ("CCPL" or "License"), in attribution 3.0 unported (Attribution Non-Commercial No Derivatives (CC BY-NC-ND)), further described at: http://creativecommons.org/license/by-nc-nd/3.0/legalcode. The work is protected by copyright and/or other applicable law. Any use of the work other then as authorized under this license or copyright law is prohibited.
spellingShingle Articles
Okamoto, Tomoyo
Kodama, Satoru
Nomi, Nozomi
Umemoto, Shingo
Suzuki, Masashi
Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
title Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
title_full Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
title_fullStr Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
title_full_unstemmed Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
title_short Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
title_sort expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390124/
https://www.ncbi.nlm.nih.gov/pubmed/22852110
http://dx.doi.org/10.2500/ar.2011.2.0004
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