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Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important?
Invasive fungal sinusitis (IFS) is a highly aggressive infection that can affect hematologic patients. The classically described general risk factors, however, do not fully explain the development of IFS in a small percentage of cases. This study examined the impact of anatomic sinonasal factors and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
OceanSide Publications, Inc.
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390131/ https://www.ncbi.nlm.nih.gov/pubmed/22852108 http://dx.doi.org/10.2500/ar.2011.2.0009 |
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author | Fernandez, Ignacio J. Stanzani, Marta Tolomelli, Giulia Pasquini, Ernesto Vianelli, Nicola Baccarani, Michele Sciarretta, Vittorio |
author_facet | Fernandez, Ignacio J. Stanzani, Marta Tolomelli, Giulia Pasquini, Ernesto Vianelli, Nicola Baccarani, Michele Sciarretta, Vittorio |
author_sort | Fernandez, Ignacio J. |
collection | PubMed |
description | Invasive fungal sinusitis (IFS) is a highly aggressive infection that can affect hematologic patients. The classically described general risk factors, however, do not fully explain the development of IFS in a small percentage of cases. This study examined the impact of anatomic sinonasal factors and environmental factors on the development of IFS in high-risk patients. Medical records and computed tomography (CT) scans of patients admitted to our institution who were at high risk of developing IFS were retrospectively reviewed. Twenty-seven patients of 797 fulfilled the inclusion criteria. Patients affected by IFS were compared with patients not affected to identify possible sinonasal and environmental risk factors of IFS. Seven patients were excluded because of the lack of adequate radiological images. Six of the 20 eligible patients were assigned to the study group of patients affected by IFS and the remaining 14 patients were assigned to the control group. All but one case developed the infection during the summer with a significantly higher mean environmental temperature (p = 0.002). Anatomic nasal alterations were found in all patients affected by IFS and were significantly more frequent than in the control group (p = 0.014). It would be advisable to have patients with hematologic risk factors of IFS, especially during the summer period, undergo endoscopic nasal assessment. Furthermore, a CT finding of anatomic nasal alterations, such as anterior nasal septum deviation causing nasal obstruction, should increase the suspicion of IFS in case of the occurrence of nasal symptoms. |
format | Online Article Text |
id | pubmed-3390131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | OceanSide Publications, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-33901312012-07-31 Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? Fernandez, Ignacio J. Stanzani, Marta Tolomelli, Giulia Pasquini, Ernesto Vianelli, Nicola Baccarani, Michele Sciarretta, Vittorio Allergy Rhinol (Providence) Articles Invasive fungal sinusitis (IFS) is a highly aggressive infection that can affect hematologic patients. The classically described general risk factors, however, do not fully explain the development of IFS in a small percentage of cases. This study examined the impact of anatomic sinonasal factors and environmental factors on the development of IFS in high-risk patients. Medical records and computed tomography (CT) scans of patients admitted to our institution who were at high risk of developing IFS were retrospectively reviewed. Twenty-seven patients of 797 fulfilled the inclusion criteria. Patients affected by IFS were compared with patients not affected to identify possible sinonasal and environmental risk factors of IFS. Seven patients were excluded because of the lack of adequate radiological images. Six of the 20 eligible patients were assigned to the study group of patients affected by IFS and the remaining 14 patients were assigned to the control group. All but one case developed the infection during the summer with a significantly higher mean environmental temperature (p = 0.002). Anatomic nasal alterations were found in all patients affected by IFS and were significantly more frequent than in the control group (p = 0.014). It would be advisable to have patients with hematologic risk factors of IFS, especially during the summer period, undergo endoscopic nasal assessment. Furthermore, a CT finding of anatomic nasal alterations, such as anterior nasal septum deviation causing nasal obstruction, should increase the suspicion of IFS in case of the occurrence of nasal symptoms. OceanSide Publications, Inc. 2011 /pmc/articles/PMC3390131/ /pubmed/22852108 http://dx.doi.org/10.2500/ar.2011.2.0009 Text en Copyright © 2011, OceanSide Publications, Inc., U.S.A. This publication is provided under the terms of the Creative Commons Public License ("CCPL" or "License"), in attribution 3.0 unported (Attribution Non-Commercial No Derivatives (CC BY-NC-ND)), further described at: http://creativecommons.org/license/by-nc-nd/3.0/legalcode. The work is protected by copyright and/or other applicable law. Any use of the work other then as authorized under this license or copyright law is prohibited. |
spellingShingle | Articles Fernandez, Ignacio J. Stanzani, Marta Tolomelli, Giulia Pasquini, Ernesto Vianelli, Nicola Baccarani, Michele Sciarretta, Vittorio Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? |
title | Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? |
title_full | Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? |
title_fullStr | Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? |
title_full_unstemmed | Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? |
title_short | Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important? |
title_sort | sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: are they important? |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390131/ https://www.ncbi.nlm.nih.gov/pubmed/22852108 http://dx.doi.org/10.2500/ar.2011.2.0009 |
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