Cargando…

Specific Inhibition of SRC Kinase Impairs Malignant Glioma Growth In Vitro and In Vivo

Malignant glioma is a severe cancer with a poor prognosis. Local occurrence and rare metastases of malignant glioma make it a suitable target for gene therapy. Several studies have demonstrated the importance of Src kinase in different cancers. However, these studies have focused mainly on Src-defic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stedt, Hanna, Alasaarela, Laura, Samaranayake, Haritha, Pikkarainen, Jere, Määttä, Ann-Marie, Kholová, Ivana, Parker, Aaron S., Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390242/ https://www.ncbi.nlm.nih.gov/pubmed/23344000 http://dx.doi.org/10.1038/mtna.2012.13

Ejemplares similares

Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells
por: Leinonen, Hanna M., et al.
Publicado: (2019)

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer
por: Sallinen, Hanna, et al.
Publicado: (2014)

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice
por: Heinonen, Suvi E, et al.
Publicado: (2011)

Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy
por: Kuusisto, Johanna, et al.
Publicado: (2012)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Experimental Evaluation of an Interferometric Light Microscopy Particle Counter for Titering and Characterization of Virus Preparations
por: Turkki, Vesa, et al.
Publicado: (2021)

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance T(RAFFn), T(1ρ) and T(2) relaxation times
por: Ylä-Herttuala, Elias, et al.
Publicado: (2023)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Short and Long-Term Effects of hVEGF-A(165) in Cre-Activated Transgenic Mice
por: Leppänen, Pia, et al.
Publicado: (2006)

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
por: Dragneva, Galina, et al.
Publicado: (2013)

Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
por: Kivelä, Antti, et al.
Publicado: (2012)

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors
por: Nousiainen, Alisa, et al.
Publicado: (2023)

A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells
por: Kärkkäinen, Hanna-Riikka, et al.
Publicado: (2009)

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
por: Husso, Tiia, et al.
Publicado: (2014)

Nucleic Acid–Based Therapies for Atherosclerosis
por: Mäkinen, Petri, et al.
Publicado: (2020)

Novel RNAi-Based Therapies for Atherosclerosis
por: Ruotsalainen, Anna-Kaisa, et al.
Publicado: (2021)

The Effect of Chemoradiotherapy with SRC Tyrosine Kinase Inhibitor, PP2 and Temozolomide on Malignant Glioma Cells In Vitro and In Vivo
por: Eom, Keun-Yong, et al.
Publicado: (2016)

Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production
por: Leinonen, Hanna M., et al.
Publicado: (2020)

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
por: Koponen, Sanna, et al.
Publicado: (2021)

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review
por: Zurek, Michelle, et al.
Publicado: (2021)

Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity
por: Turkki, Vesa, et al.
Publicado: (2014)

The role of Src family kinases in growth and migration of glioma stem cells
por: HAN, XIAOSI, et al.
Publicado: (2014)

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
por: Kujala, Anni, et al.
Publicado: (2022)

Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs
por: Laham-Karam, Nihay, et al.
Publicado: (2015)

Editorial: Vascularization for Regenerative Medicine
por: Banfi, Andrea, et al.
Publicado: (2018)

Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety
por: Leikas, Aleksi J., et al.
Publicado: (2023)

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
por: Nilsson, Ingrid, et al.
Publicado: (2010)

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion
por: Huveldt, Deborah, et al.
Publicado: (2013)

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
por: Gallini, Radiosa, et al.
Publicado: (2016)

Human Vascular Endothelial Growth Factor A(165) Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration
por: Kokki, Emmi, et al.
Publicado: (2018)

Four in one—Combination therapy using live Lactococcus lactis expressing three therapeutic proteins for the treatment of chronic non-healing wounds
por: Kurkipuro, Jere, et al.
Publicado: (2022)

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice
por: Gurzeler, Erika, et al.
Publicado: (2021)

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells
por: Mallick, Rahul, et al.
Publicado: (2022)

Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver
por: Hytönen, Elisa, et al.
Publicado: (2019)

Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5
por: Toivonen, Raine, et al.
Publicado: (2012)

COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs
por: Jiang, Miao, et al.
Publicado: (2023)

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
por: Sopo, Minna, et al.
Publicado: (2019)

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
por: Sopo, Minna, et al.
Publicado: (2020)

Comparison of Automated and Traditional Western Blotting Methods
por: Sormunen, Aino, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_epk54bp1k1qgotqmjkn7gfrl5o