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Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint

In response to DNA damage, the eukaryotic genome surveillance system activates a checkpoint kinase cascade. In the fission yeast Schizosaccharomyces pombe, checkpoint protein Crb2 is essential for DNA damage-induced activation of downstream effector kinase Chk1. The mechanism by which Crb2 mediates...

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Detalles Bibliográficos
Autores principales:	Qu, Meng, Yang, Bing, Tao, Li, Yates, John R., Russell, Paul, Dong, Meng-Qiu, Du, Li-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390401/ https://www.ncbi.nlm.nih.gov/pubmed/22792081 http://dx.doi.org/10.1371/journal.pgen.1002817

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