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Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics

Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel...

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Detalles Bibliográficos
Autor principal: Lippé, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390586/
https://www.ncbi.nlm.nih.gov/pubmed/22783234
http://dx.doi.org/10.3389/fmicb.2012.00181
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author Lippé, Roger
author_facet Lippé, Roger
author_sort Lippé, Roger
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description Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel aspect is the analysis of cellular proteins incorporated into mature virions. Though sometimes considered purification contaminants in the past, their repeated detection by different laboratories suggests that a number of these proteins are bona fide viral components, some of which likely contribute to the viral life cycles. The present mini review focuses on cellular proteins detected in herpesviruses. It highlights the common cellular functions of these proteins, their potential implications for host–pathogen interactions, discusses technical limitations, the need for complementing methods and probes potential future research avenues.
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spelling pubmed-33905862012-07-10 Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics Lippé, Roger Front Microbiol Microbiology Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel aspect is the analysis of cellular proteins incorporated into mature virions. Though sometimes considered purification contaminants in the past, their repeated detection by different laboratories suggests that a number of these proteins are bona fide viral components, some of which likely contribute to the viral life cycles. The present mini review focuses on cellular proteins detected in herpesviruses. It highlights the common cellular functions of these proteins, their potential implications for host–pathogen interactions, discusses technical limitations, the need for complementing methods and probes potential future research avenues. Frontiers Research Foundation 2012-05-28 /pmc/articles/PMC3390586/ /pubmed/22783234 http://dx.doi.org/10.3389/fmicb.2012.00181 Text en Copyright © 2012 Lippé. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Microbiology
Lippé, Roger
Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
title Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
title_full Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
title_fullStr Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
title_full_unstemmed Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
title_short Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
title_sort deciphering novel host–herpesvirus interactions by virion proteomics
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390586/
https://www.ncbi.nlm.nih.gov/pubmed/22783234
http://dx.doi.org/10.3389/fmicb.2012.00181
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