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Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390586/ https://www.ncbi.nlm.nih.gov/pubmed/22783234 http://dx.doi.org/10.3389/fmicb.2012.00181 |
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author | Lippé, Roger |
author_facet | Lippé, Roger |
author_sort | Lippé, Roger |
collection | PubMed |
description | Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel aspect is the analysis of cellular proteins incorporated into mature virions. Though sometimes considered purification contaminants in the past, their repeated detection by different laboratories suggests that a number of these proteins are bona fide viral components, some of which likely contribute to the viral life cycles. The present mini review focuses on cellular proteins detected in herpesviruses. It highlights the common cellular functions of these proteins, their potential implications for host–pathogen interactions, discusses technical limitations, the need for complementing methods and probes potential future research avenues. |
format | Online Article Text |
id | pubmed-3390586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33905862012-07-10 Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics Lippé, Roger Front Microbiol Microbiology Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel aspect is the analysis of cellular proteins incorporated into mature virions. Though sometimes considered purification contaminants in the past, their repeated detection by different laboratories suggests that a number of these proteins are bona fide viral components, some of which likely contribute to the viral life cycles. The present mini review focuses on cellular proteins detected in herpesviruses. It highlights the common cellular functions of these proteins, their potential implications for host–pathogen interactions, discusses technical limitations, the need for complementing methods and probes potential future research avenues. Frontiers Research Foundation 2012-05-28 /pmc/articles/PMC3390586/ /pubmed/22783234 http://dx.doi.org/10.3389/fmicb.2012.00181 Text en Copyright © 2012 Lippé. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Microbiology Lippé, Roger Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics |
title | Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics |
title_full | Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics |
title_fullStr | Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics |
title_full_unstemmed | Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics |
title_short | Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics |
title_sort | deciphering novel host–herpesvirus interactions by virion proteomics |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390586/ https://www.ncbi.nlm.nih.gov/pubmed/22783234 http://dx.doi.org/10.3389/fmicb.2012.00181 |
work_keys_str_mv | AT lipperoger decipheringnovelhostherpesvirusinteractionsbyvirionproteomics |