T1R3: A human calcium taste receptor

Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole re...

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Autores principales: Tordoff, Michael G., Alarcón, Laura K., Valmeki, Sitaram, Jiang, Peihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390595/
https://www.ncbi.nlm.nih.gov/pubmed/22773945
http://dx.doi.org/10.1038/srep00496
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author Tordoff, Michael G.
Alarcón, Laura K.
Valmeki, Sitaram
Jiang, Peihua
author_facet Tordoff, Michael G.
Alarcón, Laura K.
Valmeki, Sitaram
Jiang, Peihua
author_sort Tordoff, Michael G.
collection PubMed
description Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3.
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spelling pubmed-33905952012-07-06 T1R3: A human calcium taste receptor Tordoff, Michael G. Alarcón, Laura K. Valmeki, Sitaram Jiang, Peihua Sci Rep Article Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3. Nature Publishing Group 2012-07-06 /pmc/articles/PMC3390595/ /pubmed/22773945 http://dx.doi.org/10.1038/srep00496 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Tordoff, Michael G.
Alarcón, Laura K.
Valmeki, Sitaram
Jiang, Peihua
T1R3: A human calcium taste receptor
title T1R3: A human calcium taste receptor
title_full T1R3: A human calcium taste receptor
title_fullStr T1R3: A human calcium taste receptor
title_full_unstemmed T1R3: A human calcium taste receptor
title_short T1R3: A human calcium taste receptor
title_sort t1r3: a human calcium taste receptor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390595/
https://www.ncbi.nlm.nih.gov/pubmed/22773945
http://dx.doi.org/10.1038/srep00496
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AT valmekisitaram t1r3ahumancalciumtastereceptor
AT jiangpeihua t1r3ahumancalciumtastereceptor

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