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In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants

We investigated whether glyphosate influences the cellular toxicity of the surfactants TN-20 and LN-10 on the mouse fibroblast-like cells, alveolar epithelial cells, and a heart cell line. The cytotoxicity of TN-20 and LN-10 (0.4-100 µM), in the presence or absence of glyphosate was determined by as...

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Autores principales: Song, Ho-Yeon, Kim, Young-Hee, Seok, Su-Jin, Gil, Hyo-Wook, Hong, Sae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390716/
https://www.ncbi.nlm.nih.gov/pubmed/22787363
http://dx.doi.org/10.3346/jkms.2012.27.7.711
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author Song, Ho-Yeon
Kim, Young-Hee
Seok, Su-Jin
Gil, Hyo-Wook
Hong, Sae-Yong
author_facet Song, Ho-Yeon
Kim, Young-Hee
Seok, Su-Jin
Gil, Hyo-Wook
Hong, Sae-Yong
author_sort Song, Ho-Yeon
collection PubMed
description We investigated whether glyphosate influences the cellular toxicity of the surfactants TN-20 and LN-10 on the mouse fibroblast-like cells, alveolar epithelial cells, and a heart cell line. The cytotoxicity of TN-20 and LN-10 (0.4-100 µM), in the presence or absence of glyphosate was determined by assessing membrane integrity. TN-20 toxicity was significantly lower in the presence of 50 µM glyphosate for the fibroblast-like cell (6.25 µM; 3.9% ± 3.4% vs -4.8% ± 0.7%), for the alveolar cells (0.78 µM; 5.7% ± 0.9% vs 0.1% ± 0.6%), and for the heart cell line (25.0 µM; 7.9% ± 3.0% vs 19.4% ± 0.7%) compared to that of TN-20 alone. The cellular toxicity of LN-10 towards the fibroblast-like cells was found to be increased in the presence of 50 µM glyphosate when LN-10 concentrations of 50 µM (31.3% ± 3.9% vs 19.2% ± 0.9%) and 100 µM (62.1% ± 3.4% vs 39.0% ± 0.7%) were compared to that of LN-10 alone. These results suggest that the mixture toxicity may be a factor in glyphosate-surfactant toxicity in patients with acute glyphosate herbicide intoxication.
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spelling pubmed-33907162012-07-11 In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants Song, Ho-Yeon Kim, Young-Hee Seok, Su-Jin Gil, Hyo-Wook Hong, Sae-Yong J Korean Med Sci Original Article We investigated whether glyphosate influences the cellular toxicity of the surfactants TN-20 and LN-10 on the mouse fibroblast-like cells, alveolar epithelial cells, and a heart cell line. The cytotoxicity of TN-20 and LN-10 (0.4-100 µM), in the presence or absence of glyphosate was determined by assessing membrane integrity. TN-20 toxicity was significantly lower in the presence of 50 µM glyphosate for the fibroblast-like cell (6.25 µM; 3.9% ± 3.4% vs -4.8% ± 0.7%), for the alveolar cells (0.78 µM; 5.7% ± 0.9% vs 0.1% ± 0.6%), and for the heart cell line (25.0 µM; 7.9% ± 3.0% vs 19.4% ± 0.7%) compared to that of TN-20 alone. The cellular toxicity of LN-10 towards the fibroblast-like cells was found to be increased in the presence of 50 µM glyphosate when LN-10 concentrations of 50 µM (31.3% ± 3.9% vs 19.2% ± 0.9%) and 100 µM (62.1% ± 3.4% vs 39.0% ± 0.7%) were compared to that of LN-10 alone. These results suggest that the mixture toxicity may be a factor in glyphosate-surfactant toxicity in patients with acute glyphosate herbicide intoxication. The Korean Academy of Medical Sciences 2012-07 2012-06-29 /pmc/articles/PMC3390716/ /pubmed/22787363 http://dx.doi.org/10.3346/jkms.2012.27.7.711 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Ho-Yeon
Kim, Young-Hee
Seok, Su-Jin
Gil, Hyo-Wook
Hong, Sae-Yong
In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
title In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
title_full In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
title_fullStr In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
title_full_unstemmed In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
title_short In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
title_sort in vitro cytotoxic effect of glyphosate mixture containing surfactants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390716/
https://www.ncbi.nlm.nih.gov/pubmed/22787363
http://dx.doi.org/10.3346/jkms.2012.27.7.711
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