Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (1). Although bacterial lung infection and the resulting inflammation cause most of the morbidity and mortality, how loss of CFTR first disrupts airway host de...

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Detalles Bibliográficos
Autores principales: Pezzulo, Alejandro A., Tang, Xiao Xiao, Hoegger, Mark J., Abou Alaiwa, Mahmoud H., Ramachandran, Shyam, Moninger, Thomas O., Karp, Phillip H., Wohlford-Lenane, Christine L., Haagsman, Henk P., van Eijk, Martin, Bánfi, Botond, Horswill, Alexander R., Stoltz, David A., McCray, Paul B., Welsh, Michael J., Zabner, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390761/
https://www.ncbi.nlm.nih.gov/pubmed/22763554
http://dx.doi.org/10.1038/nature11130

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