USP11 augments TGFβ signalling by deubiquitylating ALK5

The TGFβ receptors signal through phosphorylation and nuclear translocation of SMAD2/3. SMAD7, a transcriptional target of TGFβ signals, negatively regulates the TGFβ pathway by recruiting E3 ubiquitin ligases and targeting TGFβ receptors for ubiquitin-mediated degradation. In this report, we identi...

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Detalles Bibliográficos
Autores principales: Al-Salihi, Mazin A., Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390794/
https://www.ncbi.nlm.nih.gov/pubmed/22773947
http://dx.doi.org/10.1098/rsob.120063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390794/
https://www.ncbi.nlm.nih.gov/pubmed/22773947
http://dx.doi.org/10.1098/rsob.120063

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