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Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life

Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified IgGs are frequently carried out in mice, but such IgGs may bind differently to mo...

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Detalles Bibliográficos
Autores principales:	Andersen, Jan Terje, Foss, Stian, Kenanova, Vania E., Olafsen, Tove, Leikfoss, Ingvild S., Roopenian, Derry C., Wu, Anna M., Sandlie, Inger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391105/ https://www.ncbi.nlm.nih.gov/pubmed/22570488 http://dx.doi.org/10.1074/jbc.M112.355131

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