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HCV Genotypes Are Differently Prone to the Development of Resistance to Linear and Macrocyclic Protease Inhibitors

BACKGROUND: Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop resistance to linear and macrocyclic protease-inhibitors (PIs). METHODS: The study includes 1568 NS3-protease sequences, isolated from PI-nai...

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Detalles Bibliográficos
Autores principales:	Cento, Valeria, Mirabelli, Carmen, Salpini, Romina, Dimonte, Salvatore, Artese, Anna, Costa, Giosuè, Mercurio, Fabio, Svicher, Valentina, Parrotta, Lucia, Bertoli, Ada, Ciotti, Marco, Di Paolo, Daniele, Sarrecchia, Cesare, Andreoni, Massimo, Alcaro, Stefano, Angelico, Mario, Perno, Carlo Federico, Ceccherini-Silberstein, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391197/ https://www.ncbi.nlm.nih.gov/pubmed/22792183 http://dx.doi.org/10.1371/journal.pone.0039652

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