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Systemic Administration of Tripeptidyl Peptidase I in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis: Effect of Glycan Modification

Late-infantile neuronal ceroid lipofuscinosis (LINCL) is a recessive genetic disease of childhood caused by deficiencies in the lysosomal protease tripeptidyl peptidase I (TPP1). Disease is characterized by progressive and extensive neuronal death. One hurdle towards development of enzyme replacemen...

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Detalles Bibliográficos
Autores principales:	Meng, Yu, Sohar, Istvan, Wang, Lingling, Sleat, David E., Lobel, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391252/ https://www.ncbi.nlm.nih.gov/pubmed/22792360 http://dx.doi.org/10.1371/journal.pone.0040509

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