Characteristic Features of Kynurenine Aminotransferase Allosterically Regulated by (Alpha)-Ketoglutarate in Cooperation with Kynurenine

Kynurenine aminotransferase from Pyrococcus horikoshii OT3 (PhKAT), which is a homodimeric protein, catalyzes the conversion of kynurenine (KYN) to kynurenic acid (KYNA). We analyzed the transaminase reaction mechanisms of this protein with pyridoxal-5′-phosphate (PLP), KYN and α-ketoglutaric acid (...

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Detalles Bibliográficos
Autores principales: Okada, Ken, Angkawidjaja, Clement, Koga, Yuichi, Takano, Kazufumi, Kanaya, Shigenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391261/
https://www.ncbi.nlm.nih.gov/pubmed/22792273
http://dx.doi.org/10.1371/journal.pone.0040307

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