Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

Sequence variants in recombinant biopharmaceuticals may have a relevant and unpredictable impact on clinical safety and efficacy. Hence, their sensitive analysis is important throughout bioprocess development. The two stage analytical approach presented here provides a quick multi clone comparison o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeck, Anne, Regula, Jörg Thomas, Larraillet, Vincent, Mautz, Björn, Popp, Oliver, Göpfert, Ulrich, Wiegeshoff, Frank, Vollertsen, Ulrike E. E., Gorr, Ingo H., Koll, Hans, Papadimitriou, Apollon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391300/
https://www.ncbi.nlm.nih.gov/pubmed/22792284
http://dx.doi.org/10.1371/journal.pone.0040328

Ejemplares similares

Ejemplares similares