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Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

Knowledge of the architecture of DNA ligase IV (LigIV) and interactions with XRCC4 and XLF-Cernunnos is necessary for understanding its role in the ligation of double-strand breaks during nonhomologous end joining. Here we report the structure of a subdomain of the nucleotidyltrasferase domain of hu...

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Detalles Bibliográficos
Autores principales:	Ochi, Takashi, Wu, Qian, Chirgadze, Dimitri Y., Grossmann, J. Günter, Bolanos-Garcia, Victor M., Blundell, Tom L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391681/ https://www.ncbi.nlm.nih.gov/pubmed/22658747 http://dx.doi.org/10.1016/j.str.2012.04.012

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