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HBZ and its roles in HTLV-1 oncogenesis
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. H...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391691/ https://www.ncbi.nlm.nih.gov/pubmed/22787458 http://dx.doi.org/10.3389/fmicb.2012.00247 |
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author | Zhao, Tiejun Matsuoka, Masao |
author_facet | Zhao, Tiejun Matsuoka, Masao |
author_sort | Zhao, Tiejun |
collection | PubMed |
description | Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5’LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5’LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response, and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL. |
format | Online Article Text |
id | pubmed-3391691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33916912012-07-11 HBZ and its roles in HTLV-1 oncogenesis Zhao, Tiejun Matsuoka, Masao Front Microbiol Microbiology Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5’LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5’LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response, and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL. Frontiers Research Foundation 2012-07-09 /pmc/articles/PMC3391691/ /pubmed/22787458 http://dx.doi.org/10.3389/fmicb.2012.00247 Text en Copyright © Zhao and Matsuoka. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Microbiology Zhao, Tiejun Matsuoka, Masao HBZ and its roles in HTLV-1 oncogenesis |
title | HBZ and its roles in HTLV-1 oncogenesis |
title_full | HBZ and its roles in HTLV-1 oncogenesis |
title_fullStr | HBZ and its roles in HTLV-1 oncogenesis |
title_full_unstemmed | HBZ and its roles in HTLV-1 oncogenesis |
title_short | HBZ and its roles in HTLV-1 oncogenesis |
title_sort | hbz and its roles in htlv-1 oncogenesis |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391691/ https://www.ncbi.nlm.nih.gov/pubmed/22787458 http://dx.doi.org/10.3389/fmicb.2012.00247 |
work_keys_str_mv | AT zhaotiejun hbzanditsrolesinhtlv1oncogenesis AT matsuokamasao hbzanditsrolesinhtlv1oncogenesis |