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HBZ and its roles in HTLV-1 oncogenesis

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. H...

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Autores principales: Zhao, Tiejun, Matsuoka, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391691/
https://www.ncbi.nlm.nih.gov/pubmed/22787458
http://dx.doi.org/10.3389/fmicb.2012.00247
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author Zhao, Tiejun
Matsuoka, Masao
author_facet Zhao, Tiejun
Matsuoka, Masao
author_sort Zhao, Tiejun
collection PubMed
description Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5’LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5’LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response, and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL.
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spelling pubmed-33916912012-07-11 HBZ and its roles in HTLV-1 oncogenesis Zhao, Tiejun Matsuoka, Masao Front Microbiol Microbiology Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5’LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5’LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response, and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL. Frontiers Research Foundation 2012-07-09 /pmc/articles/PMC3391691/ /pubmed/22787458 http://dx.doi.org/10.3389/fmicb.2012.00247 Text en Copyright © Zhao and Matsuoka. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Microbiology
Zhao, Tiejun
Matsuoka, Masao
HBZ and its roles in HTLV-1 oncogenesis
title HBZ and its roles in HTLV-1 oncogenesis
title_full HBZ and its roles in HTLV-1 oncogenesis
title_fullStr HBZ and its roles in HTLV-1 oncogenesis
title_full_unstemmed HBZ and its roles in HTLV-1 oncogenesis
title_short HBZ and its roles in HTLV-1 oncogenesis
title_sort hbz and its roles in htlv-1 oncogenesis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391691/
https://www.ncbi.nlm.nih.gov/pubmed/22787458
http://dx.doi.org/10.3389/fmicb.2012.00247
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