Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery

A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres. The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to...

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Detalles Bibliográficos
Autores principales: Barea, M. J., Jenkins, M. J., Lee, Y. S., Johnson, P., Bridson, R. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391899/
https://www.ncbi.nlm.nih.gov/pubmed/22792110
http://dx.doi.org/10.1155/2012/458712
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author Barea, M. J.
Jenkins, M. J.
Lee, Y. S.
Johnson, P.
Bridson, R. H.
author_facet Barea, M. J.
Jenkins, M. J.
Lee, Y. S.
Johnson, P.
Bridson, R. H.
author_sort Barea, M. J.
collection PubMed
description A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres. The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to improve site-specific release characteristics. In vitro drug release studies showed that LIMs prevented drug release within simulated stomach and small intestine conditions with subsequent drug release occurring in large intestine conditions. The formulation therefore has potential for oral colonic drug delivery.
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spelling pubmed-33918992012-07-12 Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery Barea, M. J. Jenkins, M. J. Lee, Y. S. Johnson, P. Bridson, R. H. Int J Biomater Research Article A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres. The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to improve site-specific release characteristics. In vitro drug release studies showed that LIMs prevented drug release within simulated stomach and small intestine conditions with subsequent drug release occurring in large intestine conditions. The formulation therefore has potential for oral colonic drug delivery. Hindawi Publishing Corporation 2012 2012-06-27 /pmc/articles/PMC3391899/ /pubmed/22792110 http://dx.doi.org/10.1155/2012/458712 Text en Copyright © 2012 M. J. Barea et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Barea, M. J.
Jenkins, M. J.
Lee, Y. S.
Johnson, P.
Bridson, R. H.
Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
title Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
title_full Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
title_fullStr Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
title_full_unstemmed Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
title_short Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
title_sort encapsulation of liposomes within ph responsive microspheres for oral colonic drug delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391899/
https://www.ncbi.nlm.nih.gov/pubmed/22792110
http://dx.doi.org/10.1155/2012/458712
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