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Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson’s disease; Crohn’s disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is sugges...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391996/ https://www.ncbi.nlm.nih.gov/pubmed/22594666 http://dx.doi.org/10.1186/1742-2094-9-94 |
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author | Greggio, Elisa Civiero, Laura Bisaglia, Marco Bubacco, Luigi |
author_facet | Greggio, Elisa Civiero, Laura Bisaglia, Marco Bubacco, Luigi |
author_sort | Greggio, Elisa |
collection | PubMed |
description | Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson’s disease; Crohn’s disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon γ, and its function as negative regulator of the immune response transcription factor NFAT1. In this review we discuss the most recent findings regarding how LRRK2 could be a player in the inflammatory response and we propose a scenario where the detrimental effects mediated by Parkinson’s disease LRRK2 mutations may initiate in the periphery and extend to the central nervous system as a consequence of increased levels of pro-inflammatory factors permeable to the blood brain barrier. |
format | Online Article Text |
id | pubmed-3391996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33919962012-07-10 Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? Greggio, Elisa Civiero, Laura Bisaglia, Marco Bubacco, Luigi J Neuroinflammation Review Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson’s disease; Crohn’s disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon γ, and its function as negative regulator of the immune response transcription factor NFAT1. In this review we discuss the most recent findings regarding how LRRK2 could be a player in the inflammatory response and we propose a scenario where the detrimental effects mediated by Parkinson’s disease LRRK2 mutations may initiate in the periphery and extend to the central nervous system as a consequence of increased levels of pro-inflammatory factors permeable to the blood brain barrier. BioMed Central 2012-07-09 /pmc/articles/PMC3391996/ /pubmed/22594666 http://dx.doi.org/10.1186/1742-2094-9-94 Text en Copyright ©2012 Greggio et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Greggio, Elisa Civiero, Laura Bisaglia, Marco Bubacco, Luigi Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? |
title | Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? |
title_full | Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? |
title_fullStr | Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? |
title_full_unstemmed | Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? |
title_short | Parkinson’s disease and immune system: is the culprit LRRKing in the periphery? |
title_sort | parkinson’s disease and immune system: is the culprit lrrking in the periphery? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391996/ https://www.ncbi.nlm.nih.gov/pubmed/22594666 http://dx.doi.org/10.1186/1742-2094-9-94 |
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