Cargando…
Allosteric modulation of caspase 3 through mutagenesis
A mutation in the allosteric site of the caspase 3 dimer interface of Val(266) to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors by preventing formation of the active site. Mutations were coupled to His(266)...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392103/ https://www.ncbi.nlm.nih.gov/pubmed/22607239 http://dx.doi.org/10.1042/BSR20120037 |