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A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression. We previously reported that the translocation red...
Autores principales: | Eykelenboom, Jennifer E., Briggs, Gareth J., Bradshaw, Nicholas J., Soares, Dinesh C., Ogawa, Fumiaki, Christie, Sheila, Malavasi, Elise L.V., Makedonopoulou, Paraskevi, Mackie, Shaun, Malloy, Mary P., Wear, Martin A., Blackburn, Elizabeth A., Bramham, Janice, McIntosh, Andrew M., Blackwood, Douglas H., Muir, Walter J., Porteous, David J., Millar, J. Kirsty |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392113/ https://www.ncbi.nlm.nih.gov/pubmed/22547224 http://dx.doi.org/10.1093/hmg/dds169 |
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