Cargando…

Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum

Mechanisms of drug resistance in Plasmodium vivax have been difficult to study partially because of the difficulties in culturing the parasite in vitro. This hampers monitoring drug resistance and research to develop or evaluate new drugs. There is an urgent need for a novel method to study mechanis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Auliff, Alyson M., Balu, Bharath, Chen, Nanhua, O’Neil, Michael T., Cheng, Qin, Adams, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392216/ https://www.ncbi.nlm.nih.gov/pubmed/22792308 http://dx.doi.org/10.1371/journal.pone.0040416

Ejemplares similares

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
por: Chaianantakul, Natpasit, et al.
Publicado: (2013)

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
por: Hawkins, Vivian N, et al.
Publicado: (2008)

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening
por: Somsak, Voravuth, et al.
Publicado: (2011)

Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment
por: Lee, Won-Ja, et al.
Publicado: (2010)

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
por: Tirakarn, Srisuda, et al.
Publicado: (2012)

Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy
por: Gresty, Karryn J, et al.
Publicado: (2014)

Genetic Polymorphisms in Plasmodium vivax Dihydrofolate Reductase and Dihydropteroate Synthase in Isolates from the Philippines, Bangladesh, and Nepal
por: Thongdee, Pimwan, et al.
Publicado: (2015)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia
por: Lau, Tiek Ying, et al.
Publicado: (2013)

Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India
por: Sharma, Divya, et al.
Publicado: (2015)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
por: Ménard, Didier, et al.
Publicado: (2008)

Molecular Docking Analysis of Pyrimethamine Derivatives with Plasmodium falciparum Dihydrofolate Reductase
por: Singh, Indra Vikram, et al.
Publicado: (2018)

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
por: Begley, Darren W., et al.
Publicado: (2011)

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum
por: Costanzo, Marna S., et al.
Publicado: (2011)

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model
por: Tipsuwan, Wachiraporn, et al.
Publicado: (2011)

The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics
por: A-Elbasit, Ishraga E, et al.
Publicado: (2007)

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes
por: Sienkiewicz, Natasha, et al.
Publicado: (2008)

Phosphorylation of Thymidylate Synthase and Dihydrofolate Reductase in Cancer Cells and the Effect of CK2α Silencing
por: Wińska, Patrycja, et al.
Publicado: (2023)

Effects of Point Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropterate Synthase Genes on Clinical Outcomes and In Vitro Susceptibility to Sulfadoxine and Pyrimethamine
por: Bacon, David J., et al.
Publicado: (2009)

Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
por: Juma, Dennis W, et al.
Publicado: (2014)

Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana
por: Osei, Musah, et al.
Publicado: (2018)

Prevalence of Dihydrofolate reductase gene mutations in Plasmodium falciparum isolate from pregnant women in Nigeria
por: Ojurongbe, Olusola, et al.
Publicado: (2011)

Comparative analysis of Plasmodium falciparum dihydrofolate-reductase gene sequences from different regions of India
por: Kumar, Amit, et al.
Publicado: (2020)

The bifunctional dihydrofolate reductase thymidylate synthase of Tetrahymena thermophila provides a tool for molecular and biotechnology applications
por: Herrmann, Lutz, et al.
Publicado: (2006)

Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases
por: Shamshad, Hina, et al.
Publicado: (2022)

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
por: Herrera-Acevedo, Chonny, et al.
Publicado: (2023)

Homology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparum
por: Alifrangis, Michael, et al.
Publicado: (2004)

Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum in Haiti
por: Carter, Tamar E, et al.
Publicado: (2012)

Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka
por: Schousboe, Mette L, et al.
Publicado: (2007)

Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi
por: Teixeira, Bárbara Velame Ferreira, et al.
Publicado: (2019)

Limited Polymorphism in the Dihydrofolate Reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand
por: Sangsri, Raweewan, et al.
Publicado: (2023)

Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras
por: Lopez, Ana Cecilia, et al.
Publicado: (2012)

Plasmodium vivax Mimicking Morphologic Features of Plasmodium falciparum
por: Ghanchi, Najia, et al.
Publicado: (2020)

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia
por: Tessema, Sofonias K., et al.
Publicado: (2015)

Carriage of Mutant Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Plasmodium falciparum Isolates Recovered from Pregnant Women with Asymptomatic Infection in Lagos, Nigeria
por: Iwalokun, Bamidele Abiodun, et al.
Publicado: (2015)

An Innovative Strategy for Dual Inhibitor Design and Its Application in Dual Inhibition of Human Thymidylate Synthase and Dihydrofolate Reductase Enzymes
por: Arooj, Mahreen, et al.
Publicado: (2013)

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase
por: Gibson, Marc W., et al.
Publicado: (2016)

Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition
por: Wang, Ping, et al.
Publicado: (2010)

Promoter regions of Plasmodium vivax are poorly or not recognized by Plasmodium falciparum
por: Azevedo, Mauro F, et al.
Publicado: (2007)

THE CULTIVATION OF MALARIAL PLASMODIA (PLASMODIUM VIVAX AND PLASMODIUM FALCIPARUM) IN VITRO
por: Bass, C. C., et al.
Publicado: (1912)

Cannot write session to /tmp/vufind_sessions/sess_0cra2hejvbqo744e3kgekeejtd