Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

BACKGROUND: Loss of function mutations in the DJ-1 gene have been linked to recessively inherited forms of Parkinsonism. Mitochondrial dysfunction and increased oxidative stress are thought to be key events in the pathogenesis of Parkinson’s disease. Although it has been reported that DJ-1 serves as...

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Detalles Bibliográficos
Autores principales: Giaime, Emilie, Yamaguchi, Hiroo, Gautier, Clement A., Kitada, Tohru, Shen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392228/
https://www.ncbi.nlm.nih.gov/pubmed/22792356
http://dx.doi.org/10.1371/journal.pone.0040501

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