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Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage
ALKBH2 is a direct DNA repair dioxygenase guarding mammalian genome against N(1)-methyladenine, N(3)-methylcytosine, and 1,N(6)-ethenoadenine damage. A prerequisite for repair is to identify these lesions in the genome. Here we present crystal structures of ALKBH2 bound to different duplex DNAs. Tog...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392526/ https://www.ncbi.nlm.nih.gov/pubmed/22659876 http://dx.doi.org/10.1038/nsmb.2320 |