Structure of STING bound to c-di-GMP Reveals the Mechanism of Cyclic Dinucleotide Recognition by the Immune System

STING, stimulator of interferon genes, is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons. STING C-terminal domain forms a V-shaped dimer and binds a c-di-GMP molecule at the dimer interface through direct and solvent-mediated hydrogen bonds. The gu...

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Detalles Bibliográficos
Autores principales: Shu, Chang, Yi, Guanghui, Watts, Tylan, Kao, C. Cheng, Li, Pingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392545/
https://www.ncbi.nlm.nih.gov/pubmed/22728658
http://dx.doi.org/10.1038/nsmb.2331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392545/
https://www.ncbi.nlm.nih.gov/pubmed/22728658
http://dx.doi.org/10.1038/nsmb.2331

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