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Can a young muscle's stem cell secretome prolong our lives?
Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remain...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392766/ https://www.ncbi.nlm.nih.gov/pubmed/22643017 http://dx.doi.org/10.1186/scrt110 |
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author | McCullagh, Karl JA |
author_facet | McCullagh, Karl JA |
author_sort | McCullagh, Karl JA |
collection | PubMed |
description | Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remains ambiguous whether these are merely an outcome of ageing or are causal. Parabiotic animal studies suggest there are factors in the systemic environment that can influence the regenerative capacity of tissues. These factors can be altered by ageing, but it is not clear where these age-dependent factors are derived. A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions. |
format | Online Article Text |
id | pubmed-3392766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33927662013-05-28 Can a young muscle's stem cell secretome prolong our lives? McCullagh, Karl JA Stem Cell Res Ther Commentary Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remains ambiguous whether these are merely an outcome of ageing or are causal. Parabiotic animal studies suggest there are factors in the systemic environment that can influence the regenerative capacity of tissues. These factors can be altered by ageing, but it is not clear where these age-dependent factors are derived. A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions. BioMed Central 2012-05-28 /pmc/articles/PMC3392766/ /pubmed/22643017 http://dx.doi.org/10.1186/scrt110 Text en Copyright ©2012 BioMed Central Ltd |
spellingShingle | Commentary McCullagh, Karl JA Can a young muscle's stem cell secretome prolong our lives? |
title | Can a young muscle's stem cell secretome prolong our lives? |
title_full | Can a young muscle's stem cell secretome prolong our lives? |
title_fullStr | Can a young muscle's stem cell secretome prolong our lives? |
title_full_unstemmed | Can a young muscle's stem cell secretome prolong our lives? |
title_short | Can a young muscle's stem cell secretome prolong our lives? |
title_sort | can a young muscle's stem cell secretome prolong our lives? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392766/ https://www.ncbi.nlm.nih.gov/pubmed/22643017 http://dx.doi.org/10.1186/scrt110 |
work_keys_str_mv | AT mccullaghkarlja canayoungmusclesstemcellsecretomeprolongourlives |