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Can a young muscle's stem cell secretome prolong our lives?

Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remain...

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Detalles Bibliográficos
Autor principal: McCullagh, Karl JA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392766/
https://www.ncbi.nlm.nih.gov/pubmed/22643017
http://dx.doi.org/10.1186/scrt110
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author McCullagh, Karl JA
author_facet McCullagh, Karl JA
author_sort McCullagh, Karl JA
collection PubMed
description Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remains ambiguous whether these are merely an outcome of ageing or are causal. Parabiotic animal studies suggest there are factors in the systemic environment that can influence the regenerative capacity of tissues. These factors can be altered by ageing, but it is not clear where these age-dependent factors are derived. A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions.
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spelling pubmed-33927662013-05-28 Can a young muscle's stem cell secretome prolong our lives? McCullagh, Karl JA Stem Cell Res Ther Commentary Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remains ambiguous whether these are merely an outcome of ageing or are causal. Parabiotic animal studies suggest there are factors in the systemic environment that can influence the regenerative capacity of tissues. These factors can be altered by ageing, but it is not clear where these age-dependent factors are derived. A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions. BioMed Central 2012-05-28 /pmc/articles/PMC3392766/ /pubmed/22643017 http://dx.doi.org/10.1186/scrt110 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Commentary
McCullagh, Karl JA
Can a young muscle's stem cell secretome prolong our lives?
title Can a young muscle's stem cell secretome prolong our lives?
title_full Can a young muscle's stem cell secretome prolong our lives?
title_fullStr Can a young muscle's stem cell secretome prolong our lives?
title_full_unstemmed Can a young muscle's stem cell secretome prolong our lives?
title_short Can a young muscle's stem cell secretome prolong our lives?
title_sort can a young muscle's stem cell secretome prolong our lives?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392766/
https://www.ncbi.nlm.nih.gov/pubmed/22643017
http://dx.doi.org/10.1186/scrt110
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