Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome

INTRODUCTION: Down syndrome (DS), a major cause of mental retardation, is caused by trisomy of some or all of human chromosome 21 and includes three basic karyotypes: trisomy 21, translocation, and mosaicism. The derivation of DS-specific induced pluripotent stem cells (iPSCs) provides us novel DS m...

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Detalles Bibliográficos
Autores principales: Mou, Xiaoning, Wu, Yuanbo, Cao, Henghua, Meng, Qingzhang, Wang, Qihui, Sun, Chengchao, Hu, Shengshou, Ma, Yue, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392774/
https://www.ncbi.nlm.nih.gov/pubmed/22512921
http://dx.doi.org/10.1186/scrt105

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