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Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Presenilin (PSEN) deficiency is accompanied by accumulation of endosomes and autophagosomes, likely caused by impaired endo-lysosomal fusion. Recently, Lee et al. (2010. Cell. doi: http://dx.doi.org/10.1016/j.cell.2010.05.008) attributed this phenomenon to PSEN1 enabling the transport of mature V0a1...

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Detalles Bibliográficos
Autores principales:	Coen, Katrijn, Flannagan, Ronald S., Baron, Szilvia, Carraro-Lacroix, Luciene R., Wang, Dong, Vermeire, Wendy, Michiels, Christine, Munck, Sebastian, Baert, Veerle, Sugita, Shuzo, Wuytack, Frank, Hiesinger, Peter Robin, Grinstein, Sergio, Annaert, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392942/ https://www.ncbi.nlm.nih.gov/pubmed/22753898 http://dx.doi.org/10.1083/jcb.201201076

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