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Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B
Liver gene transfer for hemophilia B has shown very promising results in recent clinical studies. A potential complication of gene-based treatments for hemophilia and other inherited disorders, however, is the development of neutralizing antibodies (NAb) against the therapeutic transgene. The risk o...
Autores principales: | Mingozzi, Federico, Chen, Yifeng, Murphy, Samuel L, Edmonson, Shyrie C, Tai, Alex, Price, Sandra D, Metzger, Mark E, Zhou, Shangzhen, Wright, J Fraser, Donahue, Robert E, Dunbar, Cynthia E, High, Katherine A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392987/ https://www.ncbi.nlm.nih.gov/pubmed/22565846 http://dx.doi.org/10.1038/mt.2012.84 |
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