17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione

The title compound, C(24)H(34)O(5), a fungal-transformed metabolite of the injecta­ble contraceptive medroxyprogesterone acetate, consists of four fused rings (A, B, C and D; steroid labelling). Ring A exists in a half-chair conformation while trans-fused rings B and C adopt chair conformations. The...

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Detalles Bibliográficos
Autores principales: Yousuf, Sammer, Bano, Saira, Choudhary, M. Iqbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393278/
https://www.ncbi.nlm.nih.gov/pubmed/22807835
http://dx.doi.org/10.1107/S1600536812017631
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author Yousuf, Sammer
Bano, Saira
Choudhary, M. Iqbal
author_facet Yousuf, Sammer
Bano, Saira
Choudhary, M. Iqbal
author_sort Yousuf, Sammer
collection PubMed
description The title compound, C(24)H(34)O(5), a fungal-transformed metabolite of the injecta­ble contraceptive medroxyprogesterone acetate, consists of four fused rings (A, B, C and D; steroid labelling). Ring A exists in a half-chair conformation while trans-fused rings B and C adopt chair conformations. The five-membered ring D adopts an envelope conformation with the C atom bound to the methyl group at the flap. In the crystal, adjacent mol­ecules are linked by O—H⋯O and C—H⋯O hydrogen bonds, forming infinite chains along the a axis.
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spelling pubmed-33932782012-07-17 17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione Yousuf, Sammer Bano, Saira Choudhary, M. Iqbal Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(24)H(34)O(5), a fungal-transformed metabolite of the injecta­ble contraceptive medroxyprogesterone acetate, consists of four fused rings (A, B, C and D; steroid labelling). Ring A exists in a half-chair conformation while trans-fused rings B and C adopt chair conformations. The five-membered ring D adopts an envelope conformation with the C atom bound to the methyl group at the flap. In the crystal, adjacent mol­ecules are linked by O—H⋯O and C—H⋯O hydrogen bonds, forming infinite chains along the a axis. International Union of Crystallography 2012-06-13 /pmc/articles/PMC3393278/ /pubmed/22807835 http://dx.doi.org/10.1107/S1600536812017631 Text en © Yousuf et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Yousuf, Sammer
Bano, Saira
Choudhary, M. Iqbal
17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
title 17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
title_full 17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
title_fullStr 17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
title_full_unstemmed 17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
title_short 17α-Acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
title_sort 17α-acet­oxy-11β-hy­droxy-6α-methyl­pregn-4-ene-3,20-dione
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393278/
https://www.ncbi.nlm.nih.gov/pubmed/22807835
http://dx.doi.org/10.1107/S1600536812017631
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