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Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonucleotides (AONs) modified with bridged nucleic acid...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Nakatani, Moeka, Wada, Shunsuke, Yasuhara, Hidenori, Narukawa, Keisuke, Sasaki, Kiyomi, Shibata, Masa-Aki, Torigoe, Hidetaka, Yamaoka, Tetsuji, Imanishi, Takeshi, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393380/ https://www.ncbi.nlm.nih.gov/pubmed/23344002 http://dx.doi.org/10.1038/mtna.2012.16

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