Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

BACKGROUND: Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may underlie the pathophysiology of both diseases. GSTO polymorphisms were prev...

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Detalles Bibliográficos
Autores principales: Allen, Mariet, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis S, Miles, Richard, Nair, Asha A, Crook, Julia E, Pankratz, V Shane, Carrasquillo, Minerva M, Rowley, Christopher N, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly G, Bisceglio, Gina, Ortolaza, Alexandra I, Palusak, Ryan, Middha, Sumit, Maharjan, Sooraj, Georgescu, Constantin, Schultz, Debra, Rakhshan, Fariborz, Kolbert, Christopher P, Jen, Jin, Sando, Sigrid B, Aasly, Jan O, Barcikowska, Maria, Uitti, Ryan J, Wszolek, Zbigniew K, Ross, Owen A, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393625/
https://www.ncbi.nlm.nih.gov/pubmed/22494505
http://dx.doi.org/10.1186/1750-1326-7-13

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