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Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon

BACKGROUND: People living with HIV/AIDS (PLWHA) frequently have abnormal blood counts including anemia, leucopenia and thrombocytopenia. The role of infection with plasmodia on these hematological parameters in PLWHA is not well known. In this study we compared selected hematological parameters betw...

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Autores principales: Tchinda, Gervais Gouana, Atashili, Julius, Achidi, Eric A., Kamga, Henri L., Njunda, Anna L., Ndumbe, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393653/
https://www.ncbi.nlm.nih.gov/pubmed/22802967
http://dx.doi.org/10.1371/journal.pone.0040553
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author Tchinda, Gervais Gouana
Atashili, Julius
Achidi, Eric A.
Kamga, Henri L.
Njunda, Anna L.
Ndumbe, Peter M.
author_facet Tchinda, Gervais Gouana
Atashili, Julius
Achidi, Eric A.
Kamga, Henri L.
Njunda, Anna L.
Ndumbe, Peter M.
author_sort Tchinda, Gervais Gouana
collection PubMed
description BACKGROUND: People living with HIV/AIDS (PLWHA) frequently have abnormal blood counts including anemia, leucopenia and thrombocytopenia. The role of infection with plasmodia on these hematological parameters in PLWHA is not well known. In this study we compared selected hematological parameters between malaria positive and negative PLWHA. METHODS: We conducted a cross-sectional study of PLWHA attending the Douala Laquintinie hospital. After obtaining consent, demographic and clinical data were obtained via a standardized questionnaire. Blood samples collected for hematological assays were run using an automated full blood counter. Malaria parasitaemia was determined by blood smear microscopy. RESULTS: A total of 238 adult PLWHA were enrolled, 48.3% of who were on antiretroviral therapy and 24.8% of whom had malaria parasitaemia. The respective mean (±SD) of hemoglobin level, RBC count, WBC count, platelet count, lymphocyte count and CD4+ T cell counts in malaria co-infected patients versus non-infected patients were: 10.8(±1.9) g/dl versus 11.4(±2.0)g/dl; 3,745,254(±793,353) cells/µl versus 3,888,966(±648,195) cells/µl; 4,403(±1,534) cells/µl versus 4,920(±1,922) cells/µl; 216,051(±93,884) cells/µl versus 226,792(±98,664) cells/µl; 1,846(±711) cells/µl versus 2,052(±845) cells/µl and 245(±195) cells/µl versus 301(±211) cells/µl. All these means were not statistically significantly different from each other. CONCLUSION: There was no significant difference in studied hematological parameters between malaria positive and negative PLWHA. These data suggest little or no impact of malaria infection. Hematological anomalies in PLWHA in this area need not be necessarily attributed to malaria. These need to be further investigated to identify and treat other potential causes.
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spelling pubmed-33936532012-07-16 Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon Tchinda, Gervais Gouana Atashili, Julius Achidi, Eric A. Kamga, Henri L. Njunda, Anna L. Ndumbe, Peter M. PLoS One Research Article BACKGROUND: People living with HIV/AIDS (PLWHA) frequently have abnormal blood counts including anemia, leucopenia and thrombocytopenia. The role of infection with plasmodia on these hematological parameters in PLWHA is not well known. In this study we compared selected hematological parameters between malaria positive and negative PLWHA. METHODS: We conducted a cross-sectional study of PLWHA attending the Douala Laquintinie hospital. After obtaining consent, demographic and clinical data were obtained via a standardized questionnaire. Blood samples collected for hematological assays were run using an automated full blood counter. Malaria parasitaemia was determined by blood smear microscopy. RESULTS: A total of 238 adult PLWHA were enrolled, 48.3% of who were on antiretroviral therapy and 24.8% of whom had malaria parasitaemia. The respective mean (±SD) of hemoglobin level, RBC count, WBC count, platelet count, lymphocyte count and CD4+ T cell counts in malaria co-infected patients versus non-infected patients were: 10.8(±1.9) g/dl versus 11.4(±2.0)g/dl; 3,745,254(±793,353) cells/µl versus 3,888,966(±648,195) cells/µl; 4,403(±1,534) cells/µl versus 4,920(±1,922) cells/µl; 216,051(±93,884) cells/µl versus 226,792(±98,664) cells/µl; 1,846(±711) cells/µl versus 2,052(±845) cells/µl and 245(±195) cells/µl versus 301(±211) cells/µl. All these means were not statistically significantly different from each other. CONCLUSION: There was no significant difference in studied hematological parameters between malaria positive and negative PLWHA. These data suggest little or no impact of malaria infection. Hematological anomalies in PLWHA in this area need not be necessarily attributed to malaria. These need to be further investigated to identify and treat other potential causes. Public Library of Science 2012-07-10 /pmc/articles/PMC3393653/ /pubmed/22802967 http://dx.doi.org/10.1371/journal.pone.0040553 Text en Tchinda et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tchinda, Gervais Gouana
Atashili, Julius
Achidi, Eric A.
Kamga, Henri L.
Njunda, Anna L.
Ndumbe, Peter M.
Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon
title Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon
title_full Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon
title_fullStr Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon
title_full_unstemmed Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon
title_short Impact of Malaria on Hematological Parameters in People Living with HIV/AIDS Attending the Laquintinie Hospital in Douala, Cameroon
title_sort impact of malaria on hematological parameters in people living with hiv/aids attending the laquintinie hospital in douala, cameroon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393653/
https://www.ncbi.nlm.nih.gov/pubmed/22802967
http://dx.doi.org/10.1371/journal.pone.0040553
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