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11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one

In the title compound, C(34)H(26)F(2)N(2)O(2)S, an intra­molecular O—H⋯N hydrogen bond forms an S(5) ring motif. The piperidine ring adopts a chair conformation. The thia­zolidine ring and one of the pyrrolidine rings adopt envolope conformations with methyl­ene C atoms at the flap, whereas the othe...

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Detalles Bibliográficos
Autores principales: Kumar, Raju Suresh, Osman, Hasnah, Almansour, Abdulrahman I., Arshad, Suhana, Razak, Ibrahim Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393908/
https://www.ncbi.nlm.nih.gov/pubmed/22798773
http://dx.doi.org/10.1107/S1600536812025512
Descripción
Sumario:In the title compound, C(34)H(26)F(2)N(2)O(2)S, an intra­molecular O—H⋯N hydrogen bond forms an S(5) ring motif. The piperidine ring adopts a chair conformation. The thia­zolidine ring and one of the pyrrolidine rings adopt envolope conformations with methyl­ene C atoms at the flap, whereas the other pyrrolidine ring adopts a half-chair conformation. The fluoro-substituted benzene rings form dihedral angles of 32.25 (10) and 38.27 (10)°, respectively, with the mean plane of the dihydro­acenaphthyl­ene ring system [maximum deviation = 0.043 (2) Å]. The dihedral angle between the fluoro-substituted benzene rings is 64.13 (14)°. In the crystal, mol­ecules are linked by weak C—H⋯O, C—H⋯F and C—H⋯S hydrogen bonds into a three-dimensional network.