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11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one

In the title compound, C(34)H(26)F(2)N(2)O(2)S, an intra­molecular O—H⋯N hydrogen bond forms an S(5) ring motif. The piperidine ring adopts a chair conformation. The thia­zolidine ring and one of the pyrrolidine rings adopt envolope conformations with methyl­ene C atoms at the flap, whereas the othe...

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Autores principales: Kumar, Raju Suresh, Osman, Hasnah, Almansour, Abdulrahman I., Arshad, Suhana, Razak, Ibrahim Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393908/
https://www.ncbi.nlm.nih.gov/pubmed/22798773
http://dx.doi.org/10.1107/S1600536812025512
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author Kumar, Raju Suresh
Osman, Hasnah
Almansour, Abdulrahman I.
Arshad, Suhana
Razak, Ibrahim Abdul
author_facet Kumar, Raju Suresh
Osman, Hasnah
Almansour, Abdulrahman I.
Arshad, Suhana
Razak, Ibrahim Abdul
author_sort Kumar, Raju Suresh
collection PubMed
description In the title compound, C(34)H(26)F(2)N(2)O(2)S, an intra­molecular O—H⋯N hydrogen bond forms an S(5) ring motif. The piperidine ring adopts a chair conformation. The thia­zolidine ring and one of the pyrrolidine rings adopt envolope conformations with methyl­ene C atoms at the flap, whereas the other pyrrolidine ring adopts a half-chair conformation. The fluoro-substituted benzene rings form dihedral angles of 32.25 (10) and 38.27 (10)°, respectively, with the mean plane of the dihydro­acenaphthyl­ene ring system [maximum deviation = 0.043 (2) Å]. The dihedral angle between the fluoro-substituted benzene rings is 64.13 (14)°. In the crystal, mol­ecules are linked by weak C—H⋯O, C—H⋯F and C—H⋯S hydrogen bonds into a three-dimensional network.
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spelling pubmed-33939082012-07-13 11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one Kumar, Raju Suresh Osman, Hasnah Almansour, Abdulrahman I. Arshad, Suhana Razak, Ibrahim Abdul Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(34)H(26)F(2)N(2)O(2)S, an intra­molecular O—H⋯N hydrogen bond forms an S(5) ring motif. The piperidine ring adopts a chair conformation. The thia­zolidine ring and one of the pyrrolidine rings adopt envolope conformations with methyl­ene C atoms at the flap, whereas the other pyrrolidine ring adopts a half-chair conformation. The fluoro-substituted benzene rings form dihedral angles of 32.25 (10) and 38.27 (10)°, respectively, with the mean plane of the dihydro­acenaphthyl­ene ring system [maximum deviation = 0.043 (2) Å]. The dihedral angle between the fluoro-substituted benzene rings is 64.13 (14)°. In the crystal, mol­ecules are linked by weak C—H⋯O, C—H⋯F and C—H⋯S hydrogen bonds into a three-dimensional network. International Union of Crystallography 2012-06-13 /pmc/articles/PMC3393908/ /pubmed/22798773 http://dx.doi.org/10.1107/S1600536812025512 Text en © Kumar et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Kumar, Raju Suresh
Osman, Hasnah
Almansour, Abdulrahman I.
Arshad, Suhana
Razak, Ibrahim Abdul
11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
title 11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
title_full 11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
title_fullStr 11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
title_full_unstemmed 11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
title_short 11-[(E)-2-Fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
title_sort 11-[(e)-2-fluoro­benzyl­idene]-8-(2-fluoro­phen­yl)-14-hy­droxy-6-thia-3,13-diaza­hepta­cyclo­[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393908/
https://www.ncbi.nlm.nih.gov/pubmed/22798773
http://dx.doi.org/10.1107/S1600536812025512
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