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2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine
In the title compound, C(20)H(18)BrN(5), the bromophenyl-substituted quinazoline unit is essentially planar [maximum deviation = 0.098 (3) Å] and makes a dihedral angle of 56.04 (14)° with the imidazole ring. In the crystal, molecules are associated by pairs of N—H⋯N hydrogen bonds to form inversi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394037/ https://www.ncbi.nlm.nih.gov/pubmed/22798902 http://dx.doi.org/10.1107/S1600536812028115 |
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author | Pérez-Fehrmann, Marcia Kesternich, Victor Verdugo, Felipe Christen, Philippe Besnard, Céline |
author_facet | Pérez-Fehrmann, Marcia Kesternich, Victor Verdugo, Felipe Christen, Philippe Besnard, Céline |
author_sort | Pérez-Fehrmann, Marcia |
collection | PubMed |
description | In the title compound, C(20)H(18)BrN(5), the bromophenyl-substituted quinazoline unit is essentially planar [maximum deviation = 0.098 (3) Å] and makes a dihedral angle of 56.04 (14)° with the imidazole ring. In the crystal, molecules are associated by pairs of N—H⋯N hydrogen bonds to form inversion dimers. All the quinazoline planar systems are oriented almost perpendicular to the [110] direction, making π–π interactions possible between adjacent dimers [centroid–centroid distances = 3.7674 (16) and 3.7612 (17) Å]. There are also a number of C—H⋯π interactions present. The crystal is a nonmerohedral twin, with a minor twin fraction of 0.47. |
format | Online Article Text |
id | pubmed-3394037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-33940372012-07-13 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine Pérez-Fehrmann, Marcia Kesternich, Victor Verdugo, Felipe Christen, Philippe Besnard, Céline Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(20)H(18)BrN(5), the bromophenyl-substituted quinazoline unit is essentially planar [maximum deviation = 0.098 (3) Å] and makes a dihedral angle of 56.04 (14)° with the imidazole ring. In the crystal, molecules are associated by pairs of N—H⋯N hydrogen bonds to form inversion dimers. All the quinazoline planar systems are oriented almost perpendicular to the [110] direction, making π–π interactions possible between adjacent dimers [centroid–centroid distances = 3.7674 (16) and 3.7612 (17) Å]. There are also a number of C—H⋯π interactions present. The crystal is a nonmerohedral twin, with a minor twin fraction of 0.47. International Union of Crystallography 2012-06-30 /pmc/articles/PMC3394037/ /pubmed/22798902 http://dx.doi.org/10.1107/S1600536812028115 Text en © Pérez-Fehrmann et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Pérez-Fehrmann, Marcia Kesternich, Victor Verdugo, Felipe Christen, Philippe Besnard, Céline 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine |
title | 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine |
title_full | 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine |
title_fullStr | 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine |
title_full_unstemmed | 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine |
title_short | 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine |
title_sort | 2-(4-bromophenyl)-n-[3-(1h-imidazol-1-yl)propyl]quinazolin-4-amine |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394037/ https://www.ncbi.nlm.nih.gov/pubmed/22798902 http://dx.doi.org/10.1107/S1600536812028115 |
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