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Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells

BACKGROUND: Tissue factor (TF), an initiator of blood coagulation, participates in cancer progression and metastasis. We recently found that inhibition of MAPK/ERK upregulated both full length TF (flTF) and soluble isoform TF (asTF) gene expression and cell-associated TF activity in breast cancer MD...

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Detalles Bibliográficos
Autores principales:	Hu, Chaoquan, Huang, Limin, Gest, Caroline, Xi, Xiaodong, Janin, Anne, Soria, Claudine, Li, Hong, Lu, He
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394220/ https://www.ncbi.nlm.nih.gov/pubmed/22534171 http://dx.doi.org/10.1186/1756-8722-5-16

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