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GalaxyWEB server for protein structure prediction and refinement
Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394311/ https://www.ncbi.nlm.nih.gov/pubmed/22649060 http://dx.doi.org/10.1093/nar/gks493 |
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author | Ko, Junsu Park, Hahnbeom Heo, Lim Seok, Chaok |
author_facet | Ko, Junsu Park, Hahnbeom Heo, Lim Seok, Chaok |
author_sort | Ko, Junsu |
collection | PubMed |
description | Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server is based on the method tested in CASP9 (9th Critical Assessment of techniques for protein Structure Prediction) as ‘Seok-server’, which was assessed to be among top performing template-based modeling servers. The method generates reliable core structures from multiple templates and re-builds unreliable loops or termini by using an optimization-based refinement method. In addition to structure prediction, a user can also submit a refinement only job by providing a starting model structure and locations of loops or termini to refine. The web server can be freely accessed at http://galaxy.seoklab.org/. |
format | Online Article Text |
id | pubmed-3394311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33943112012-07-30 GalaxyWEB server for protein structure prediction and refinement Ko, Junsu Park, Hahnbeom Heo, Lim Seok, Chaok Nucleic Acids Res Articles Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server is based on the method tested in CASP9 (9th Critical Assessment of techniques for protein Structure Prediction) as ‘Seok-server’, which was assessed to be among top performing template-based modeling servers. The method generates reliable core structures from multiple templates and re-builds unreliable loops or termini by using an optimization-based refinement method. In addition to structure prediction, a user can also submit a refinement only job by providing a starting model structure and locations of loops or termini to refine. The web server can be freely accessed at http://galaxy.seoklab.org/. Oxford University Press 2012-07 2012-05-30 /pmc/articles/PMC3394311/ /pubmed/22649060 http://dx.doi.org/10.1093/nar/gks493 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Ko, Junsu Park, Hahnbeom Heo, Lim Seok, Chaok GalaxyWEB server for protein structure prediction and refinement |
title | GalaxyWEB server for protein structure prediction and refinement |
title_full | GalaxyWEB server for protein structure prediction and refinement |
title_fullStr | GalaxyWEB server for protein structure prediction and refinement |
title_full_unstemmed | GalaxyWEB server for protein structure prediction and refinement |
title_short | GalaxyWEB server for protein structure prediction and refinement |
title_sort | galaxyweb server for protein structure prediction and refinement |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394311/ https://www.ncbi.nlm.nih.gov/pubmed/22649060 http://dx.doi.org/10.1093/nar/gks493 |
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