Cargando…

GalaxyWEB server for protein structure prediction and refinement

Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server...

Descripción completa

Detalles Bibliográficos
Autores principales: Ko, Junsu, Park, Hahnbeom, Heo, Lim, Seok, Chaok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394311/
https://www.ncbi.nlm.nih.gov/pubmed/22649060
http://dx.doi.org/10.1093/nar/gks493
_version_ 1782237851457421312
author Ko, Junsu
Park, Hahnbeom
Heo, Lim
Seok, Chaok
author_facet Ko, Junsu
Park, Hahnbeom
Heo, Lim
Seok, Chaok
author_sort Ko, Junsu
collection PubMed
description Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server is based on the method tested in CASP9 (9th Critical Assessment of techniques for protein Structure Prediction) as ‘Seok-server’, which was assessed to be among top performing template-based modeling servers. The method generates reliable core structures from multiple templates and re-builds unreliable loops or termini by using an optimization-based refinement method. In addition to structure prediction, a user can also submit a refinement only job by providing a starting model structure and locations of loops or termini to refine. The web server can be freely accessed at http://galaxy.seoklab.org/.
format Online
Article
Text
id pubmed-3394311
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-33943112012-07-30 GalaxyWEB server for protein structure prediction and refinement Ko, Junsu Park, Hahnbeom Heo, Lim Seok, Chaok Nucleic Acids Res Articles Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server is based on the method tested in CASP9 (9th Critical Assessment of techniques for protein Structure Prediction) as ‘Seok-server’, which was assessed to be among top performing template-based modeling servers. The method generates reliable core structures from multiple templates and re-builds unreliable loops or termini by using an optimization-based refinement method. In addition to structure prediction, a user can also submit a refinement only job by providing a starting model structure and locations of loops or termini to refine. The web server can be freely accessed at http://galaxy.seoklab.org/. Oxford University Press 2012-07 2012-05-30 /pmc/articles/PMC3394311/ /pubmed/22649060 http://dx.doi.org/10.1093/nar/gks493 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Ko, Junsu
Park, Hahnbeom
Heo, Lim
Seok, Chaok
GalaxyWEB server for protein structure prediction and refinement
title GalaxyWEB server for protein structure prediction and refinement
title_full GalaxyWEB server for protein structure prediction and refinement
title_fullStr GalaxyWEB server for protein structure prediction and refinement
title_full_unstemmed GalaxyWEB server for protein structure prediction and refinement
title_short GalaxyWEB server for protein structure prediction and refinement
title_sort galaxyweb server for protein structure prediction and refinement
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394311/
https://www.ncbi.nlm.nih.gov/pubmed/22649060
http://dx.doi.org/10.1093/nar/gks493
work_keys_str_mv AT kojunsu galaxywebserverforproteinstructurepredictionandrefinement
AT parkhahnbeom galaxywebserverforproteinstructurepredictionandrefinement
AT heolim galaxywebserverforproteinstructurepredictionandrefinement
AT seokchaok galaxywebserverforproteinstructurepredictionandrefinement