Cargando…
MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis
First released in 2009, MetaboAnalyst (www.metaboanalyst.ca) was a relatively simple web server designed to facilitate metabolomic data processing and statistical analysis. With continuing advances in metabolomics along with constant user feedback, it became clear that a substantial upgrade to the o...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394314/ https://www.ncbi.nlm.nih.gov/pubmed/22553367 http://dx.doi.org/10.1093/nar/gks374 |
_version_ | 1782237852113829888 |
---|---|
author | Xia, Jianguo Mandal, Rupasri Sinelnikov, Igor V. Broadhurst, David Wishart, David S. |
author_facet | Xia, Jianguo Mandal, Rupasri Sinelnikov, Igor V. Broadhurst, David Wishart, David S. |
author_sort | Xia, Jianguo |
collection | PubMed |
description | First released in 2009, MetaboAnalyst (www.metaboanalyst.ca) was a relatively simple web server designed to facilitate metabolomic data processing and statistical analysis. With continuing advances in metabolomics along with constant user feedback, it became clear that a substantial upgrade to the original server was necessary. MetaboAnalyst 2.0, which is the successor to MetaboAnalyst, represents just such an upgrade. MetaboAnalyst 2.0 now contains dozens of new features and functions including new procedures for data filtering, data editing and data normalization. It also supports multi-group data analysis, two-factor analysis as well as time-series data analysis. These new functions have also been supplemented with: (i) a quality-control module that allows users to evaluate their data quality before conducting any analysis, (ii) a functional enrichment analysis module that allows users to identify biologically meaningful patterns using metabolite set enrichment analysis and (iii) a metabolic pathway analysis module that allows users to perform pathway analysis and visualization for 15 different model organisms. In developing MetaboAnalyst 2.0 we have also substantially improved its graphical presentation tools. All images are now generated using anti-aliasing and are available over a range of resolutions, sizes and formats (PNG, TIFF, PDF, PostScript, or SVG). To improve its performance, MetaboAnalyst 2.0 is now hosted on a much more powerful server with substantially modified code to take advantage the server’s multi-core CPUs for computationally intensive tasks. MetaboAnalyst 2.0 also maintains a collection of 50 or more FAQs and more than a dozen tutorials compiled from user queries and requests. A downloadable version of MetaboAnalyst 2.0, along detailed instructions for local installation is now available as well. |
format | Online Article Text |
id | pubmed-3394314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33943142012-07-30 MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis Xia, Jianguo Mandal, Rupasri Sinelnikov, Igor V. Broadhurst, David Wishart, David S. Nucleic Acids Res Articles First released in 2009, MetaboAnalyst (www.metaboanalyst.ca) was a relatively simple web server designed to facilitate metabolomic data processing and statistical analysis. With continuing advances in metabolomics along with constant user feedback, it became clear that a substantial upgrade to the original server was necessary. MetaboAnalyst 2.0, which is the successor to MetaboAnalyst, represents just such an upgrade. MetaboAnalyst 2.0 now contains dozens of new features and functions including new procedures for data filtering, data editing and data normalization. It also supports multi-group data analysis, two-factor analysis as well as time-series data analysis. These new functions have also been supplemented with: (i) a quality-control module that allows users to evaluate their data quality before conducting any analysis, (ii) a functional enrichment analysis module that allows users to identify biologically meaningful patterns using metabolite set enrichment analysis and (iii) a metabolic pathway analysis module that allows users to perform pathway analysis and visualization for 15 different model organisms. In developing MetaboAnalyst 2.0 we have also substantially improved its graphical presentation tools. All images are now generated using anti-aliasing and are available over a range of resolutions, sizes and formats (PNG, TIFF, PDF, PostScript, or SVG). To improve its performance, MetaboAnalyst 2.0 is now hosted on a much more powerful server with substantially modified code to take advantage the server’s multi-core CPUs for computationally intensive tasks. MetaboAnalyst 2.0 also maintains a collection of 50 or more FAQs and more than a dozen tutorials compiled from user queries and requests. A downloadable version of MetaboAnalyst 2.0, along detailed instructions for local installation is now available as well. Oxford University Press 2012-07 2012-05-02 /pmc/articles/PMC3394314/ /pubmed/22553367 http://dx.doi.org/10.1093/nar/gks374 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Xia, Jianguo Mandal, Rupasri Sinelnikov, Igor V. Broadhurst, David Wishart, David S. MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis |
title | MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis |
title_full | MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis |
title_fullStr | MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis |
title_full_unstemmed | MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis |
title_short | MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis |
title_sort | metaboanalyst 2.0—a comprehensive server for metabolomic data analysis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394314/ https://www.ncbi.nlm.nih.gov/pubmed/22553367 http://dx.doi.org/10.1093/nar/gks374 |
work_keys_str_mv | AT xiajianguo metaboanalyst20acomprehensiveserverformetabolomicdataanalysis AT mandalrupasri metaboanalyst20acomprehensiveserverformetabolomicdataanalysis AT sinelnikovigorv metaboanalyst20acomprehensiveserverformetabolomicdataanalysis AT broadhurstdavid metaboanalyst20acomprehensiveserverformetabolomicdataanalysis AT wishartdavids metaboanalyst20acomprehensiveserverformetabolomicdataanalysis |