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Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

Previous studies demonstrate the initiation of colon cancers through deregulation of WNT-TCF signalling. An accepted but untested extension of this finding is that incurable metastatic colon carcinomas (CCs) universally remain WNT-TCF-dependent, prompting the search for WNT-TCF inhibitors. CCs and t...

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Detalles Bibliográficos
Autores principales:	Varnat, Frédéric, Siegl-Cachedenier, Irene, Malerba, Monica, Gervaz, Pascal, Ruiz i Altaba, Ariel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394505/ https://www.ncbi.nlm.nih.gov/pubmed/20941789 http://dx.doi.org/10.1002/emmm.201000098

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