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Viruses and Interactomes in Translation
A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (E...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Biochemistry and Molecular Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394946/ https://www.ncbi.nlm.nih.gov/pubmed/22371486 http://dx.doi.org/10.1074/mcp.M111.014738 |
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author | Meyniel-Schicklin, Laurène de Chassey, Benoît André, Patrice Lotteau, Vincent |
author_facet | Meyniel-Schicklin, Laurène de Chassey, Benoît André, Patrice Lotteau, Vincent |
author_sort | Meyniel-Schicklin, Laurène |
collection | PubMed |
description | A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (EBV, FLUAV, HCV, HSV-1, KSHV, SARS-CoV, VACV, and VZV) and virus-host protein networks (DENV, EBV, FLUAV, HCV, and VACV) from up-to-date interaction data, using various mathematical approaches. If intraviral networks seem to behave similarly, they are clearly different from the human interactome. Viral proteins target highly central human proteins, which are precisely the Achilles' heel of the human interactome. The intrinsic structural disorder is a distinctive feature of viral hubs in virus-host interactomes. Overlaps between virus-host data sets identify a core of human proteins involved in the cellular response to viral infection and in the viral capacity to hijack the cell machinery for viral replication. Host proteins that are strongly targeted by a virus seem to be particularly attractive for other viruses. Such protein-protein interaction networks and their analysis represent a powerful resource from a therapeutic perspective. |
format | Online Article Text |
id | pubmed-3394946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-33949462013-07-01 Viruses and Interactomes in Translation Meyniel-Schicklin, Laurène de Chassey, Benoît André, Patrice Lotteau, Vincent Mol Cell Proteomics Research A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (EBV, FLUAV, HCV, HSV-1, KSHV, SARS-CoV, VACV, and VZV) and virus-host protein networks (DENV, EBV, FLUAV, HCV, and VACV) from up-to-date interaction data, using various mathematical approaches. If intraviral networks seem to behave similarly, they are clearly different from the human interactome. Viral proteins target highly central human proteins, which are precisely the Achilles' heel of the human interactome. The intrinsic structural disorder is a distinctive feature of viral hubs in virus-host interactomes. Overlaps between virus-host data sets identify a core of human proteins involved in the cellular response to viral infection and in the viral capacity to hijack the cell machinery for viral replication. Host proteins that are strongly targeted by a virus seem to be particularly attractive for other viruses. Such protein-protein interaction networks and their analysis represent a powerful resource from a therapeutic perspective. The American Society for Biochemistry and Molecular Biology 2012-07 2012-02-27 /pmc/articles/PMC3394946/ /pubmed/22371486 http://dx.doi.org/10.1074/mcp.M111.014738 Text en © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. |
spellingShingle | Research Meyniel-Schicklin, Laurène de Chassey, Benoît André, Patrice Lotteau, Vincent Viruses and Interactomes in Translation |
title | Viruses and Interactomes in Translation |
title_full | Viruses and Interactomes in Translation |
title_fullStr | Viruses and Interactomes in Translation |
title_full_unstemmed | Viruses and Interactomes in Translation |
title_short | Viruses and Interactomes in Translation |
title_sort | viruses and interactomes in translation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394946/ https://www.ncbi.nlm.nih.gov/pubmed/22371486 http://dx.doi.org/10.1074/mcp.M111.014738 |
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