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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

BACKGROUND: Most solid tumours contain regions of sub-optimal oxygen concentration (hypoxia). Hypoxic cancer cells are more resistant to radiotherapy and represent the most aggressive fraction of a tumour. It is therefore essential that strategies continue to be developed to target hypoxic cancer ce...

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Detalles Bibliográficos
Autores principales:	Pires, I M, Olcina, M M, Anbalagan, S, Pollard, J R, Reaper, P M, Charlton, P A, McKenna, W G, Hammond, E M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394988/ https://www.ncbi.nlm.nih.gov/pubmed/22713662 http://dx.doi.org/10.1038/bjc.2012.265

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