Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report

A two-year-old girl with congenital dyserythropoietic anemia (CDA) acutely developed fever, tachypnea, and increased oxygen requirement. Chest X-ray revealed bilateral interstitial infiltrates and mild cardiomegaly. Blood cultures grew no infectious agents, while pulmonary specimens grew cytomegalov...

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Detalles Bibliográficos
Autores principales: Carden, Marcus A., Barman, Ashish, Massey, Gita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395170/
https://www.ncbi.nlm.nih.gov/pubmed/22953144
http://dx.doi.org/10.1155/2012/624740
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author Carden, Marcus A.
Barman, Ashish
Massey, Gita
author_facet Carden, Marcus A.
Barman, Ashish
Massey, Gita
author_sort Carden, Marcus A.
collection PubMed
description A two-year-old girl with congenital dyserythropoietic anemia (CDA) acutely developed fever, tachypnea, and increased oxygen requirement. Chest X-ray revealed bilateral interstitial infiltrates and mild cardiomegaly. Blood cultures grew no infectious agents, while pulmonary specimens grew cytomegalovirus (CMV). Treatment with intravenous ganciclovir was initiated but without response. Final cytologic preparations of bronchoalveolar lavage (BAL) fluid revealed eosinophilic amorphous material consistent with pulmonary alveolar proteinosis (PAP). CDA and PAP are extremely rare disorders in pediatrics. PAP should be considered in patients with hematological disorders who present with acute interstitial pneumonia, after infectious causes are ruled out.
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spelling pubmed-33951702012-09-05 Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report Carden, Marcus A. Barman, Ashish Massey, Gita Case Rep Pediatr Case Report A two-year-old girl with congenital dyserythropoietic anemia (CDA) acutely developed fever, tachypnea, and increased oxygen requirement. Chest X-ray revealed bilateral interstitial infiltrates and mild cardiomegaly. Blood cultures grew no infectious agents, while pulmonary specimens grew cytomegalovirus (CMV). Treatment with intravenous ganciclovir was initiated but without response. Final cytologic preparations of bronchoalveolar lavage (BAL) fluid revealed eosinophilic amorphous material consistent with pulmonary alveolar proteinosis (PAP). CDA and PAP are extremely rare disorders in pediatrics. PAP should be considered in patients with hematological disorders who present with acute interstitial pneumonia, after infectious causes are ruled out. Hindawi Publishing Corporation 2012 2012-06-28 /pmc/articles/PMC3395170/ /pubmed/22953144 http://dx.doi.org/10.1155/2012/624740 Text en Copyright © 2012 Marcus A. Carden et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Carden, Marcus A.
Barman, Ashish
Massey, Gita
Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
title Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
title_full Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
title_fullStr Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
title_full_unstemmed Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
title_short Pulmonary Alveolar Proteinosis in Association with Congenital Dyserythropoietic Anemia: A Case Report
title_sort pulmonary alveolar proteinosis in association with congenital dyserythropoietic anemia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395170/
https://www.ncbi.nlm.nih.gov/pubmed/22953144
http://dx.doi.org/10.1155/2012/624740
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