The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency

The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obe...

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Detalles Bibliográficos
Autores principales: Tsou, Ryan C., Bence, Kendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395189/
https://www.ncbi.nlm.nih.gov/pubmed/22811891
http://dx.doi.org/10.1155/2012/926857
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author Tsou, Ryan C.
Bence, Kendra K.
author_facet Tsou, Ryan C.
Bence, Kendra K.
author_sort Tsou, Ryan C.
collection PubMed
description The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obesity and type 2 diabetes. The PTP1B protein is encoded by the PTPN1 gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity in human populations. In this paper, we summarize the genetics of the PTPN1 locus and associations with metabolic disease. In addition, we discuss the tissue-specific functions of PTP1B as gleaned from genetic mouse models.
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spelling pubmed-33951892012-07-18 The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency Tsou, Ryan C. Bence, Kendra K. J Obes Review Article The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obesity and type 2 diabetes. The PTP1B protein is encoded by the PTPN1 gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity in human populations. In this paper, we summarize the genetics of the PTPN1 locus and associations with metabolic disease. In addition, we discuss the tissue-specific functions of PTP1B as gleaned from genetic mouse models. Hindawi Publishing Corporation 2012 2012-07-01 /pmc/articles/PMC3395189/ /pubmed/22811891 http://dx.doi.org/10.1155/2012/926857 Text en Copyright © 2012 R. C. Tsou and K. K. Bence. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tsou, Ryan C.
Bence, Kendra K.
The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
title The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
title_full The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
title_fullStr The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
title_full_unstemmed The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
title_short The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
title_sort genetics of ptpn1 and obesity: insights from mouse models of tissue-specific ptp1b deficiency
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395189/
https://www.ncbi.nlm.nih.gov/pubmed/22811891
http://dx.doi.org/10.1155/2012/926857
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