Cargando…
Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In order to overcome the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395194/ https://www.ncbi.nlm.nih.gov/pubmed/22811764 http://dx.doi.org/10.1155/2012/324256 |
_version_ | 1782237950979866624 |
---|---|
author | Fujita, Kyota Yamafuji, Megumi Nakabeppu, Yusaku Noda, Mami |
author_facet | Fujita, Kyota Yamafuji, Megumi Nakabeppu, Yusaku Noda, Mami |
author_sort | Fujita, Kyota |
collection | PubMed |
description | Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In order to overcome the oxidative damage, there are some protective signaling pathways related to transcriptional upregulation of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and superoxide dismutase (SOD)-1/-2. Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). These antioxidant enzymes are associated with, and in some cases, prevent neuronal death in animal models of neurodegenerative diseases. They are activated by endogenous mediators and phytochemicals, and also by several gases such as carbon monoxide (CO), hydrogen sulphide (H(2)S), and hydrogen (H(2)). These might thereby protect the brain from severe oxidative damage and resultant neurodegenerative diseases. In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated. We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-3395194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33951942012-07-18 Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes Fujita, Kyota Yamafuji, Megumi Nakabeppu, Yusaku Noda, Mami Oxid Med Cell Longev Review Article Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In order to overcome the oxidative damage, there are some protective signaling pathways related to transcriptional upregulation of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and superoxide dismutase (SOD)-1/-2. Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). These antioxidant enzymes are associated with, and in some cases, prevent neuronal death in animal models of neurodegenerative diseases. They are activated by endogenous mediators and phytochemicals, and also by several gases such as carbon monoxide (CO), hydrogen sulphide (H(2)S), and hydrogen (H(2)). These might thereby protect the brain from severe oxidative damage and resultant neurodegenerative diseases. In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated. We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases. Hindawi Publishing Corporation 2012 2012-07-01 /pmc/articles/PMC3395194/ /pubmed/22811764 http://dx.doi.org/10.1155/2012/324256 Text en Copyright © 2012 Kyota Fujita et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fujita, Kyota Yamafuji, Megumi Nakabeppu, Yusaku Noda, Mami Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes |
title | Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes |
title_full | Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes |
title_fullStr | Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes |
title_full_unstemmed | Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes |
title_short | Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes |
title_sort | therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395194/ https://www.ncbi.nlm.nih.gov/pubmed/22811764 http://dx.doi.org/10.1155/2012/324256 |
work_keys_str_mv | AT fujitakyota therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes AT yamafujimegumi therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes AT nakabeppuyusaku therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes AT nodamami therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes |