Cargando…

Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes

Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In order to overcome the...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujita, Kyota, Yamafuji, Megumi, Nakabeppu, Yusaku, Noda, Mami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395194/
https://www.ncbi.nlm.nih.gov/pubmed/22811764
http://dx.doi.org/10.1155/2012/324256
_version_ 1782237950979866624
author Fujita, Kyota
Yamafuji, Megumi
Nakabeppu, Yusaku
Noda, Mami
author_facet Fujita, Kyota
Yamafuji, Megumi
Nakabeppu, Yusaku
Noda, Mami
author_sort Fujita, Kyota
collection PubMed
description Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In order to overcome the oxidative damage, there are some protective signaling pathways related to transcriptional upregulation of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and superoxide dismutase (SOD)-1/-2. Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). These antioxidant enzymes are associated with, and in some cases, prevent neuronal death in animal models of neurodegenerative diseases. They are activated by endogenous mediators and phytochemicals, and also by several gases such as carbon monoxide (CO), hydrogen sulphide (H(2)S), and hydrogen (H(2)). These might thereby protect the brain from severe oxidative damage and resultant neurodegenerative diseases. In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated. We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases.
format Online
Article
Text
id pubmed-3395194
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33951942012-07-18 Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes Fujita, Kyota Yamafuji, Megumi Nakabeppu, Yusaku Noda, Mami Oxid Med Cell Longev Review Article Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In order to overcome the oxidative damage, there are some protective signaling pathways related to transcriptional upregulation of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and superoxide dismutase (SOD)-1/-2. Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). These antioxidant enzymes are associated with, and in some cases, prevent neuronal death in animal models of neurodegenerative diseases. They are activated by endogenous mediators and phytochemicals, and also by several gases such as carbon monoxide (CO), hydrogen sulphide (H(2)S), and hydrogen (H(2)). These might thereby protect the brain from severe oxidative damage and resultant neurodegenerative diseases. In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated. We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases. Hindawi Publishing Corporation 2012 2012-07-01 /pmc/articles/PMC3395194/ /pubmed/22811764 http://dx.doi.org/10.1155/2012/324256 Text en Copyright © 2012 Kyota Fujita et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fujita, Kyota
Yamafuji, Megumi
Nakabeppu, Yusaku
Noda, Mami
Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
title Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
title_full Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
title_fullStr Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
title_full_unstemmed Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
title_short Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes
title_sort therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395194/
https://www.ncbi.nlm.nih.gov/pubmed/22811764
http://dx.doi.org/10.1155/2012/324256
work_keys_str_mv AT fujitakyota therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes
AT yamafujimegumi therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes
AT nakabeppuyusaku therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes
AT nodamami therapeuticapproachtoneurodegenerativediseasesbymedicalgasesfocusingonredoxsignalingandrelatedantioxidantenzymes