Synthesis, Biological Evaluation, and Structure–Activity Relationships of Novel Substituted N-Phenyl Ureidobenzenesulfonate Derivatives Blocking Cell Cycle Progression in S-Phase and Inducing DNA Double-Strand Breaks

[Image: see text] Twenty-eight new substituted N-phenyl ureidobenzenesulfonate (PUB-SO) and 18 N-phenylureidobenzenesulfonamide (PUB-SA) derivatives were prepared. Several PUB-SOs exhibited antiproliferative activity at the micromolar level against the HT-29, M21, and MCF-7 cell lines and blocked ce...

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Detalles Bibliográficos
Autores principales: Turcotte, Vanessa, Fortin, Sébastien, Vevey, Florence, Coulombe, Yan, Lacroix, Jacques, Côté, Marie-France, Masson, Jean-Yves, C.-Gaudreault, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395254/
https://www.ncbi.nlm.nih.gov/pubmed/22694057
http://dx.doi.org/10.1021/jm3006492

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