A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS: Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression

Objectives. To determine if therapy with pioglitazone HCl and tretinoin could slow disease progression in patients with ALS. Levels of tau and pNFH in the cerebrospinal fluid were measured to see if they could serve as prognostic indicators. Methods. 27 subjects on stable doses of riluzole were enro...

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Detalles Bibliográficos
Autores principales: Levine, Todd D., Bowser, Robert, Hank, Nicole C., Gately, Stephen, Stephan, Dietrich, Saperstein, David S., Van Keuren-Jensen, Kendall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395264/
https://www.ncbi.nlm.nih.gov/pubmed/22830016
http://dx.doi.org/10.1155/2012/582075

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