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Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet

The effect of C. odontophyllum (CO) fruit parts was investigated in hypercholesterolemic rabbits. Forty-nine rabbits, which were randomly divided into seven groups of seven animals (n = 7), received a diet containing different parts of CO fruit parts for 8 weeks. The groups were as follows: (1) norm...

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Autores principales: Shakirin, Faridah Hanim, Azlan, Azrina, Ismail, Amin, Amom, Zulkhairi, Yuon, Lau Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395265/
https://www.ncbi.nlm.nih.gov/pubmed/22811751
http://dx.doi.org/10.1155/2012/838604
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author Shakirin, Faridah Hanim
Azlan, Azrina
Ismail, Amin
Amom, Zulkhairi
Yuon, Lau Cheng
author_facet Shakirin, Faridah Hanim
Azlan, Azrina
Ismail, Amin
Amom, Zulkhairi
Yuon, Lau Cheng
author_sort Shakirin, Faridah Hanim
collection PubMed
description The effect of C. odontophyllum (CO) fruit parts was investigated in hypercholesterolemic rabbits. Forty-nine rabbits, which were randomly divided into seven groups of seven animals (n = 7), received a diet containing different parts of CO fruit parts for 8 weeks. The groups were as follows: (1) normal diet: NC group and (2) hypercholesterolemic diet: PC, HS (10 mg/kg/day simvastatin), HPO (20 g kg(−1) oil extracted from the pulp of CO), HKO (20 g kg(−1) oil extracted from the kernel of CO), HF (50 g kg(−1) fullfat pulp of CO), and HD (50 g kg(−1) defatted pulp of CO). Among these groups, rabbits receiving defatted pulp of CO showed the greatest cholesterol lowering effect as it had reduced plasma LDL-C, TC, and thiobarbiturate reactive substance (TBARS) levels as well as atherosclerotic plaques. The presence of high dietary fiber and antioxidants activity are potential factors contributing to the cholesterol lowering effect. Consequently, these results indicate the potential use of CO defatted pulp as a cholesterol lowering and antioxidant agent.
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spelling pubmed-33952652012-07-18 Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet Shakirin, Faridah Hanim Azlan, Azrina Ismail, Amin Amom, Zulkhairi Yuon, Lau Cheng Evid Based Complement Alternat Med Research Article The effect of C. odontophyllum (CO) fruit parts was investigated in hypercholesterolemic rabbits. Forty-nine rabbits, which were randomly divided into seven groups of seven animals (n = 7), received a diet containing different parts of CO fruit parts for 8 weeks. The groups were as follows: (1) normal diet: NC group and (2) hypercholesterolemic diet: PC, HS (10 mg/kg/day simvastatin), HPO (20 g kg(−1) oil extracted from the pulp of CO), HKO (20 g kg(−1) oil extracted from the kernel of CO), HF (50 g kg(−1) fullfat pulp of CO), and HD (50 g kg(−1) defatted pulp of CO). Among these groups, rabbits receiving defatted pulp of CO showed the greatest cholesterol lowering effect as it had reduced plasma LDL-C, TC, and thiobarbiturate reactive substance (TBARS) levels as well as atherosclerotic plaques. The presence of high dietary fiber and antioxidants activity are potential factors contributing to the cholesterol lowering effect. Consequently, these results indicate the potential use of CO defatted pulp as a cholesterol lowering and antioxidant agent. Hindawi Publishing Corporation 2012 2012-07-01 /pmc/articles/PMC3395265/ /pubmed/22811751 http://dx.doi.org/10.1155/2012/838604 Text en Copyright © 2012 Faridah Hanim Shakirin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shakirin, Faridah Hanim
Azlan, Azrina
Ismail, Amin
Amom, Zulkhairi
Yuon, Lau Cheng
Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet
title Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet
title_full Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet
title_fullStr Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet
title_full_unstemmed Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet
title_short Antiatherosclerotic Effect of Canarium odontophyllum Miq. Fruit Parts in Rabbits Fed High Cholesterol Diet
title_sort antiatherosclerotic effect of canarium odontophyllum miq. fruit parts in rabbits fed high cholesterol diet
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395265/
https://www.ncbi.nlm.nih.gov/pubmed/22811751
http://dx.doi.org/10.1155/2012/838604
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