Control and Augmentation of Long-Term Plasmid Transgene Expression In Vivo in Murine Muscle Tissue and Ex Vivo in Patient Mesenchymal Tissue

Purpose. In vivo gene therapy directed at tissues of mesenchymal origin could potentially augment healing. We aimed to assess the duration and magnitude of transene expression in vivo in mice and ex vivo in human tissues. Methods. Using bioluminescence imaging, plasmid and adenoviral vector-based tr...

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Detalles Bibliográficos
Autores principales: Morrissey, David, van Pijkeren, Jan P., Rajendran, Simon, Collins, Sara A., Casey, Garrett, O'Sullivan, Gerald C., Tangney, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395381/
https://www.ncbi.nlm.nih.gov/pubmed/22811595
http://dx.doi.org/10.1155/2012/379845

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