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Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range

Recently, the wavelength range around 1060 nm has become attractive for retinal imaging with optical coherence tomography (OCT), promising deep penetration into the retina and the choroid. The adjacent water absorption bands limit the useful bandwidth of broadband light sources, but until now, the a...

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Autores principales: Marschall, Sebastian, Pedersen, Christian, Andersen, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395486/
https://www.ncbi.nlm.nih.gov/pubmed/22808433
http://dx.doi.org/10.1364/BOE.3.001620
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author Marschall, Sebastian
Pedersen, Christian
Andersen, Peter E.
author_facet Marschall, Sebastian
Pedersen, Christian
Andersen, Peter E.
author_sort Marschall, Sebastian
collection PubMed
description Recently, the wavelength range around 1060 nm has become attractive for retinal imaging with optical coherence tomography (OCT), promising deep penetration into the retina and the choroid. The adjacent water absorption bands limit the useful bandwidth of broadband light sources, but until now, the actual limitation has not been quantified in detail. We have numerically investigated the impact of water absorption on the axial resolution and signal amplitude for a wide range of light source bandwidths and center wavelengths. Furthermore, we have calculated the sensitivity penalty for maintaining the optimal resolution by spectral shaping. As our results show, with currently available semiconductor-based light sources with up to 100–120 nm bandwidth centered close to 1060 nm, the resolution degradation caused by the water absorption spectrum is smaller than 10%, and it can be compensated by spectral shaping with negligible sensitivity penalty. With increasing bandwidth, the resolution degradation and signal attenuation become stronger, and the optimal operating point shifts towards shorter wavelengths. These relationships are important to take into account for the development of new broadband light sources for OCT.
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spelling pubmed-33954862012-07-17 Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range Marschall, Sebastian Pedersen, Christian Andersen, Peter E. Biomed Opt Express Optical Coherence Tomography Recently, the wavelength range around 1060 nm has become attractive for retinal imaging with optical coherence tomography (OCT), promising deep penetration into the retina and the choroid. The adjacent water absorption bands limit the useful bandwidth of broadband light sources, but until now, the actual limitation has not been quantified in detail. We have numerically investigated the impact of water absorption on the axial resolution and signal amplitude for a wide range of light source bandwidths and center wavelengths. Furthermore, we have calculated the sensitivity penalty for maintaining the optimal resolution by spectral shaping. As our results show, with currently available semiconductor-based light sources with up to 100–120 nm bandwidth centered close to 1060 nm, the resolution degradation caused by the water absorption spectrum is smaller than 10%, and it can be compensated by spectral shaping with negligible sensitivity penalty. With increasing bandwidth, the resolution degradation and signal attenuation become stronger, and the optimal operating point shifts towards shorter wavelengths. These relationships are important to take into account for the development of new broadband light sources for OCT. Optical Society of America 2012-06-18 /pmc/articles/PMC3395486/ /pubmed/22808433 http://dx.doi.org/10.1364/BOE.3.001620 Text en © 2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Optical Coherence Tomography
Marschall, Sebastian
Pedersen, Christian
Andersen, Peter E.
Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range
title Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range
title_full Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range
title_fullStr Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range
title_full_unstemmed Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range
title_short Investigation of the impact of water absorption on retinal OCT imaging in the 1060 nm range
title_sort investigation of the impact of water absorption on retinal oct imaging in the 1060 nm range
topic Optical Coherence Tomography
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395486/
https://www.ncbi.nlm.nih.gov/pubmed/22808433
http://dx.doi.org/10.1364/BOE.3.001620
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