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Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans

ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using m...

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Detalles Bibliográficos
Autores principales: Zhang, Jingdan, Zhou, Shaohua Kevin, Xiang, Xiaoyan, Bautista, Merrick L., Niccum, Blake A., Dickinson, Gabriel S., Tan, I-Chih, Chan, Wenyaw, Sevick-Muraca, Eva M., Rasmussen, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395493/
https://www.ncbi.nlm.nih.gov/pubmed/22808440
http://dx.doi.org/10.1364/BOE.3.001713
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author Zhang, Jingdan
Zhou, Shaohua Kevin
Xiang, Xiaoyan
Bautista, Merrick L.
Niccum, Blake A.
Dickinson, Gabriel S.
Tan, I-Chih
Chan, Wenyaw
Sevick-Muraca, Eva M.
Rasmussen, John C.
author_facet Zhang, Jingdan
Zhou, Shaohua Kevin
Xiang, Xiaoyan
Bautista, Merrick L.
Niccum, Blake A.
Dickinson, Gabriel S.
Tan, I-Chih
Chan, Wenyaw
Sevick-Muraca, Eva M.
Rasmussen, John C.
author_sort Zhang, Jingdan
collection PubMed
description ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans.
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spelling pubmed-33954932012-07-17 Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans Zhang, Jingdan Zhou, Shaohua Kevin Xiang, Xiaoyan Bautista, Merrick L. Niccum, Blake A. Dickinson, Gabriel S. Tan, I-Chih Chan, Wenyaw Sevick-Muraca, Eva M. Rasmussen, John C. Biomed Opt Express Image Processing ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans. Optical Society of America 2012-06-22 /pmc/articles/PMC3395493/ /pubmed/22808440 http://dx.doi.org/10.1364/BOE.3.001713 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Image Processing
Zhang, Jingdan
Zhou, Shaohua Kevin
Xiang, Xiaoyan
Bautista, Merrick L.
Niccum, Blake A.
Dickinson, Gabriel S.
Tan, I-Chih
Chan, Wenyaw
Sevick-Muraca, Eva M.
Rasmussen, John C.
Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
title Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
title_full Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
title_fullStr Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
title_full_unstemmed Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
title_short Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
title_sort automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
topic Image Processing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395493/
https://www.ncbi.nlm.nih.gov/pubmed/22808440
http://dx.doi.org/10.1364/BOE.3.001713
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