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Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395493/ https://www.ncbi.nlm.nih.gov/pubmed/22808440 http://dx.doi.org/10.1364/BOE.3.001713 |
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author | Zhang, Jingdan Zhou, Shaohua Kevin Xiang, Xiaoyan Bautista, Merrick L. Niccum, Blake A. Dickinson, Gabriel S. Tan, I-Chih Chan, Wenyaw Sevick-Muraca, Eva M. Rasmussen, John C. |
author_facet | Zhang, Jingdan Zhou, Shaohua Kevin Xiang, Xiaoyan Bautista, Merrick L. Niccum, Blake A. Dickinson, Gabriel S. Tan, I-Chih Chan, Wenyaw Sevick-Muraca, Eva M. Rasmussen, John C. |
author_sort | Zhang, Jingdan |
collection | PubMed |
description | ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans. |
format | Online Article Text |
id | pubmed-3395493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-33954932012-07-17 Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans Zhang, Jingdan Zhou, Shaohua Kevin Xiang, Xiaoyan Bautista, Merrick L. Niccum, Blake A. Dickinson, Gabriel S. Tan, I-Chih Chan, Wenyaw Sevick-Muraca, Eva M. Rasmussen, John C. Biomed Opt Express Image Processing ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans. Optical Society of America 2012-06-22 /pmc/articles/PMC3395493/ /pubmed/22808440 http://dx.doi.org/10.1364/BOE.3.001713 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Image Processing Zhang, Jingdan Zhou, Shaohua Kevin Xiang, Xiaoyan Bautista, Merrick L. Niccum, Blake A. Dickinson, Gabriel S. Tan, I-Chih Chan, Wenyaw Sevick-Muraca, Eva M. Rasmussen, John C. Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
title | Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
title_full | Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
title_fullStr | Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
title_full_unstemmed | Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
title_short | Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
title_sort | automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans |
topic | Image Processing |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395493/ https://www.ncbi.nlm.nih.gov/pubmed/22808440 http://dx.doi.org/10.1364/BOE.3.001713 |
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